Podoplanin Protein (PDPN) (His tag)
Quick Overview for Podoplanin Protein (PDPN) (His tag) (ABIN7320345)
抗原
See all Podoplanin (PDPN) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Podoplanin protein is labelled with His tag.
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原理
- Recombinant Mouse Podoplanin/PDPN Protein (His Tag)
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序列
- Met 1-Lys 133
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产品特性
- A DNA sequence encoding the mouse PDPN N-terminal fragment (NP_034459.2) (Met 1-Lys 133) was expressed,with a C-terminal polyhistidine tag.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Podoplanin (PDPN) protein (Fc Tag)
PDPN 宿主: 小鼠 宿主: 人细胞 Recombinant > 90 % as determined by reducing SDS-PAGE.
Podoplanin (PDPN) (AA 99-207) protein (His tag)PDPN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS - PAGE SDS
Podoplanin (PDPN) (AA 23-141) protein (His tag)PDPN 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Podoplanin (PDPN) (AA 1-238) protein (GST tag)PDPN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Podoplanin (PDPN) (Active) protein (His tag,Fc Tag)PDPN 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
Podoplanin (PDPN) protein (Fc Tag,ECD)PDPN 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Podoplanin (PDPN)
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别名
- Podoplanin/PDPN
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背景
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Background: Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: Gp38;OTS-8;RANDAM-2;T1-alpha;T1a;T1alpha;Podoplanin; Aggrus; Glycoprotein 38; PA2.26 antigen
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分子量
- 13 kDa
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NCBI登录号
- NP_034459
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途径
- Dicarboxylic Acid Transport
抗原
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