PSPH 蛋白
Quick Overview for PSPH 蛋白 (ABIN7317234)
抗原
See all PSPH 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human PSPH Protein
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序列
- Met 1-Glu 225
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产品特性
- A DNA sequence encoding the human PSPH (P78330) (Met 1-Glu 225) was expressed and purified.
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Phosphoserine Phosphatase (PSPH) (AA 1-225) protein (His tag)
custom-made PSPH 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Phosphoserine Phosphatase (PSPH) (AA 1-225) protein (His tag)custom-made PSPH 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Phosphoserine Phosphatase (PSPH) (AA 1-225) protein (GST tag)PSPH 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Phosphoserine Phosphatase (PSPH) (AA 1-382) protein (His tag)PSPH 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % pure SDS
Phosphoserine Phosphatase (PSPH) protein (Myc-DYKDDDDK Tag)PSPH 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.5
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- PSPH (Phosphoserine Phosphatase (PSPH))
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别名
- PSPH
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背景
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Background: Phosphoserine phosphatase (PSPH) belongs to a subfamily of the phosphotransferases. PSPH is the rate-limiting enzyme in l-serine biosynthesis. It has previously been found that Phosphoserine phosphatase (PSPH) plays a role in epidermal homeostasis. Phosphoserine phosphatase (PSP) catalyzes the hydrolysis of phosphoserine to serine. Phosphoserine phosphatase (PSPH) expression has been examined in human-mouse somatic cell hybrids retaining different combination of human chromosomes. Phosphoserine phosphatase (PSPH) is expressed throughout the proliferative layer of the epidermis and hair follicles in rodent and human skin and is highly induced in SCC. In keratinocytes, Phosphoserine phosphatase (PSPH) is a cytoplasmic protein that primarily localizes to endosomes and is present primarily as a homodimer. Knock down of Phosphoserine phosphatase (PSPH) dramatically diminished SCC cell proliferation and cyclin D1 levels in the presence of exogenous of l-serine production suggesting a non-canonical role for Phosphoserine phosphatase (PSPH) in epithelial carcinogenesis. Phosphoserine phosphatase (PSPH) is highly induced in proliferative normal keratinocytes and in skin tumors. Phosphoserine phosphatase (PSPH) appears to be critical for the proliferation of SCC cells, however, this phenomenon may not involve the phosphoserine metabolic pathway.
Synonym: Phosphoserine Phosphatase, PSP, PSPase, L-3-Phosphoserine Phosphatase, O-Phosphoserine Phosphohydrolase, PSPH
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分子量
- 25 kDa
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UniProt
- P78330
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途径
- Warburg Effect
抗原
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