PDE9A Protein (His-GST)
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Quick Overview for PDE9A Protein (His-GST) (ABIN7317496)
抗原
See all PDE9A 蛋白蛋白类型
宿主
资源
纯度
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标记
- This PDE9A protein is labelled with His-GST.
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原理
- Recombinant Human PDE9A Protein (His & GST Tag)
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序列
- Met 1-Ala 533
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产品特性
- A DNA sequence encoding the full length of human PDE9A (O76083-2) (Met 1-Ala 533) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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phosphodiesterase 9A (PDE9A) (AA 434-533) protein (GST tag)
PDE9A 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
phosphodiesterase 9A (PDE9A) (AA 1-533) protein (GST tag)PDE9A 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
phosphodiesterase 9A (PDE9A) (Transcript Variant 9) protein (Myc-DYKDDDDK Tag)PDE9A 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
phosphodiesterase 9A (PDE9A) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag)PDE9A 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
phosphodiesterase 9A (PDE9A) (Transcript Variant 13) protein (Myc-DYKDDDDK Tag)PDE9A 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 5 mM GSH, pH 7.4, 10 % glycerol
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- PDE9A (phosphodiesterase 9A (PDE9A))
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别名
- PDE9A
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背景
- HSPDE9A2,High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, also known as PDE9A, is a member of the cyclic nucleotide phosphodiesterase family and PDE9 subfamily. PDE9A is expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels of PDE9A is in brain, heart, kidney, spleen, prostate and colon. IsoformPDE9A12is found in prostate. PDE9A mRNA is widely distributed throughout the rat and mouse brain, with the highest expression observed in cerebellar Purkinje cells.PDE9A is the only cGMP-specific PDE with significant expression in the forebrain, and as such is likely to play an important role in NO-cGMP signaling. PDE9A is highly conserved between species and is widely distributed throughout the rodent brain. PDE9A is probably involved in maintenance of low cGMP levels in cells and might play an important role in a variety of brain functions involving cGMP-mediated signal transduction. PDE9A hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. PDE9A represents a novel drug target worthy of further study.
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分子量
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Calculated MW: 89.5 kDa
Observed MW: 75 kDa
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基因ID
- 5152
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UniProt
- O76083
抗原
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