PDE1C Protein (His-GST)
This Recombinant PDE1C protein is expressed in Baculovirus infected Insect Cells.
产品编号 ABIN7197331
发货至:
中国
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Contact Info
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中国
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Quick Overview for PDE1C Protein (His-GST) (ABIN7197331)
抗原
See all PDE1C 蛋白
PDE1C
(phosphodiesterase 1C, Calmodulin-Dependent 70kDa (PDE1C))
蛋白类型
Recombinant
宿主
人
资源
Baculovirus infected Insect Cells
纯度
> 85 % as determined by reducing SDS-PAGE.
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标记
- This PDE1C protein is labelled with His-GST.
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原理
- Recombinant Human PDE1C Protein (His & GST Tag)
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序列
- Met 1-Glu634
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产品特性
- A DNA sequence encoding the human PDE1C (Q8TAE4) (Met1-Glu634) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol, 3 mM DTT
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存液
- Dithiothreitol (DTT)
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注意事项
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- PDE1C (phosphodiesterase 1C, Calmodulin-Dependent 70kDa (PDE1C))
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别名
- PDE1C
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背景
- Hcam3,cam-PDE1C,hCam-3,PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory. PDE1C has a high affinity for both cAMP and cGMP. It is expressed in several tissues, including brain and heart. As a cyclic nucleotide phosphodiesterase, PDE1C has a dual-specificity for the second messengers cAMP and cGMP.
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分子量
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Calculated MW: 100 kDa
Observed MW: 97 kDa
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UniProt
- Q8TAE4
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途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
抗原
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