PDE1B Protein (His-GST)
This Recombinant PDE1B protein is expressed in Baculovirus infected Insect Cells.
产品编号 ABIN7317495
发货至:
中国
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Quick Overview for PDE1B Protein (His-GST) (ABIN7317495)
抗原
See all PDE1B 蛋白
PDE1B
(phosphodiesterase 1B, Calmodulin-Dependent (PDE1B))
蛋白类型
Recombinant
宿主
人
资源
Baculovirus infected Insect Cells
纯度
> 94 % as determined by reducing SDS-PAGE.
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标记
- This PDE1B protein is labelled with His-GST.
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原理
- Recombinant Human PDE1B Protein (His & GST Tag)
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序列
- Met 1-Asp 536
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产品特性
- A DNA sequence encoding the human PDE1B long isoform (Q01064-1) (Met 1-Asp 536) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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phosphodiesterase 1B, Calmodulin-Dependent (PDE1B) (AA 437-536) protein (GST tag)
PDE1B 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
phosphodiesterase 1B, Calmodulin-Dependent (PDE1B) protein (Myc-DYKDDDDK Tag)PDE1B 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- PDE1B (phosphodiesterase 1B, Calmodulin-Dependent (PDE1B))
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别名
- PDE1B
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背景
- PDE1B1,PDES1B,Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein which belongs to thecyclic nucleotide phosphodiesterase family and PDE1 subfamily. Phosphodiesterase-10A (PDE10A), Phosphodiesterase-1B (PDE1B), Phosphodiesterase-4B (PDE4B), and Phosphodiesterase-4A (PDE4A) are important regulators of signal transduction in striatum due to their catalysis of cyclic AMP and cyclic GMP. PDE1B is highly expressed in the striatum. It binds two divalent metal cations per subunit. Site one of PDE1B may preferentially bind zinc ions, while site two of PDE1B has a preference for magnesium and/or manganese ions. PDE1B is a cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. It has a preference for cGMP as a substrate.
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分子量
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Calculated MW: 89.2 kDa
Observed MW: 75 kDa
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基因ID
- 5153
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UniProt
- Q01064
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途径
- Neurotrophin Signaling Pathway, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
抗原
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