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PPIA 蛋白

This Recombinant PPIA protein is expressed in 大肠杆菌(E. Coli).
产品编号 ABIN7319370
发货至: 中国

Quick Overview for PPIA 蛋白 (ABIN7319370)

抗原

See all PPIA 蛋白
PPIA (Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA))

蛋白类型

Recombinant

宿主

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资源

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大肠杆菌(E. Coli)

纯度

> 95 % as determined by reducing SDS-PAGE.
  • 原理

    Recombinant Human Cyclophilin A Protein

    序列

    Met 1-Glu165

    产品特性

    Recombinant Human Peptidyl-prolyl Cis-trans Isomerase A is produced by our E.coli expression system and the target gene encoding Met1-Glu165 is expressed.

    内毒素水平

    < 1.0 EU per μg as determined by the LAL method.
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    Product
    表达系统
    Conjugate
    Origin
    价格从
    表达系统 HEK-293 Cells
    Conjugate His tag
    Origin Human
    价格从 106,314.67 ¥
    表达系统 Cell-free protein synthesis (CFPS)
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    Origin Human
    价格从 172,528.32 ¥

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  • 限制

    仅限研究用
  • 状态

    Frozen, Liquid

    缓冲液

    Supplied as a 0.2 μm filtered solution of PBS, 10 % glycerol, pH 7.4 .

    储存条件

    -20 °C

    储存方法

    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • 抗原

    PPIA (Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA))

    别名

    Cyclophilin A

    背景

    Background: Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biological processes, including intracellular signaling, transcription, inflammation, and apoptosis. Cyclophilin is also incorporated into many viruses, including HIV1, where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit calcineurin phosphatase activity and prevent incorporation of cyclophilin into viral particles. The cyclosporin/cyclophilin complex selectively binds and inactivates calcineurin, making it a useful inhibitor for studying calcineurin activity.

    Synonym: Peptidyl-prolyl cis-trans isomerase A, PPIase A, Cyclophilin A, Cyclosporin A-binding protein, Rotamase A, SP18, PPIA, CYPA

    分子量

    18 kDa

    UniProt

    P62937
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