PTX3 Protein (His tag)
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Quick Overview for PTX3 Protein (His tag) (ABIN7317420)
抗原
See all PTX3 蛋白蛋白类型
宿主
资源
纯度
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标记
- This PTX3 protein is labelled with His tag.
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原理
- Recombinant Human PTX3/Pentraxin 3/TSG-14 Protein (His Tag)
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序列
- Met 1-Ser 381
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产品特性
- A DNA sequence encoding the human PTX3 (NP_002843.2) (Met 1-Ser 381) was fused with a polyhistidine tag at the C-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Pentraxin 3 (PTX3) (AA 183-381) protein
PTX3 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS, WB, ELISA, IP
Pentraxin 3 (PTX3) (AA 18-381) protein (His tag)PTX3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % SDS
Pentraxin 3 (PTX3) (AA 282-380) protein (GST tag)PTX3 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- PTX3 (Pentraxin 3 (PTX3))
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别名
- PTX3/Pentraxin 3/TSG-14
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背景
- PTX3,TNFAIP5,TSG-14,Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein which contains onepentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.
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分子量
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Calculated MW: 41.6 kDa
Observed MW: 43-47 kDa
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基因ID
- 5806
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NCBI登录号
- NP_002843
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UniProt
- P26022
抗原
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