PAPPA2 Protein (His tag)
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Quick Overview for PAPPA2 Protein (His tag) (ABIN7317837)
抗原
See all PAPPA2 蛋白蛋白类型
宿主
资源
纯度
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标记
- This PAPPA2 protein is labelled with His tag.
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原理
- Recombinant Human PAPPA2/Pappalysin 2 Protein (His Tag)
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序列
- Ser 234-Cys 1396
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产品特性
- A DNA sequence encoding the human PAPPA2 mature form (NP_064714.2) corresponding to amino acid (Ser 234-Cys 1396) was expressed, with a carboxy-terminal polyhistidine tag.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Pappalysin 2 (PAPPA2) protein
PAPPA2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS, WB, ELISA, IP
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- PAPPA2 (Pappalysin 2 (PAPPA2))
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别名
- PAPPA2/Pappalysin 2
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背景
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Background: Pappalysin-2/PAPP-A2 is the second member of the pappalysin family of metzincin superfamily, of which PAPP-A is the first member. There is no homology between the prepro-peptides of PAPP-A and PAPP-A2, but 46 % of the residues of mature PAPP-A are also present in mature PAPP-A2. PAPP-A specifically cleaves insulin-like growth factor-binding protein(IGFBP)-4, one of six known modulators of IGF-I and -II, whereas PAPP-A2 specifically cleaved IGFBP-5 at one site, between Ser-143 and Lys-144. In contrast to the cleavage of IGFBP-4 by PAPP-A that strictly requires the presence of IGF, the cleavage of IGFBP-5 by PAPP-A2 was IGF-independent. Recent data firmly establish PAPP-A and IGFBP-4 as an important functional pair in several systems. Because of its close relationship with PAPP-A, both structurally and functionally, PAPP-A2 is a likely candidate for IGFBP-5 proteinase in many tissues and conditioned media where IGFBP-5 proteolysis has been reported.
Synonym: PAPP-A2,PAPP-E,PAPPE,PLAC3
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分子量
- 131 kDa
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NCBI登录号
- NP_064714
抗原
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