Osteoactivin Protein (GPNMB) (Fc Tag)
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Quick Overview for Osteoactivin Protein (GPNMB) (Fc Tag) (ABIN7317588)
抗原
See all Osteoactivin (GPNMB) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Osteoactivin protein is labelled with Fc Tag.
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原理
- Recombinant Human GPNMB Protein (Fc Tag)
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序列
- Met 1-Pro474
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产品特性
- A DNA sequence encoding the human GPNMB (Q14956-2) (Met1-Pro474) was expressed with the Fc region of human IgG1 at the C-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Osteoactivin (GPNMB) (AA 23-496) protein (His tag)
GPNMB 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Osteoactivin (GPNMB) (AA 23-502) (Active) protein (His tag)GPNMB 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Osteoactivin (GPNMB) (AA 23-486) (Active) protein (His tag)GPNMB 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Osteoactivin (GPNMB) (AA 1-572) protein (GST tag)GPNMB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Osteoactivin (GPNMB) (AA 22-474) protein (His tag)GPNMB 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % SDS
Osteoactivin (GPNMB) (AA 22-474) protein (His tag)GPNMB 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % SDS
Osteoactivin (GPNMB) (AA 1-502) protein (His tag)GPNMB 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
Osteoactivin (GPNMB) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)GPNMB 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- Osteoactivin (GPNMB)
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别名
- GPNMB
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背景
- GPNMB,HGFIN,NMB,Osteoactivin,Transmembrane Glycoprotein HGFIN,Transmembrane Glycoprotein NMB,GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteoclasts, macrophages, dendritic cells, and tumor cells. It is suggested to influence osteoblast maturation, cell adhesion and migration. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages. Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury. The early-phase upregulation of Osteoactivin expression in the tubular epithelium in response to renal injury might play a role in triggering renal interstitial fibrosis via activation of matrix metalloproteinase expression and collagen remodeling in rats. Osteoactivin as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone.
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分子量
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Calculated MW: 77.8 kDa
Observed MW: 114 kDa
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基因ID
- 10457
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UniProt
- Q14956
抗原
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