Osteoactivin Protein (GPNMB) (Fc Tag)
Quick Overview for Osteoactivin Protein (GPNMB) (Fc Tag) (ABIN7317588)
抗原
See all Osteoactivin (GPNMB) 蛋白蛋白类型
宿主
资源
纯度
-
-
标记
- This Osteoactivin protein is labelled with Fc Tag.
-
原理
- Recombinant Human GPNMB Protein (Fc Tag)
-
序列
- Met 1-Pro474
-
产品特性
- A DNA sequence encoding the human GPNMB (Q14956-2) (Met1-Pro474) was expressed with the Fc region of human IgG1 at the C-terminus.
-
内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
-
-
Osteoactivin (GPNMB) (AA 23-502) protein (His tag)
GPNMB 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Osteoactivin (GPNMB) (AA 23-486) protein (His tag)GPNMB 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Osteoactivin (GPNMB) (AA 23-496) protein (His tag)GPNMB 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Osteoactivin (GPNMB) (AA 22-474) protein (His tag)GPNMB 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
Osteoactivin (GPNMB) (AA 22-474) protein (His tag)GPNMB 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % by SDS - PAGE SDS
Osteoactivin (GPNMB) (AA 1-572) protein (GST tag)GPNMB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Osteoactivin (GPNMB) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)GPNMB 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Please refer to the printed manual for detailed information.
-
缓冲液
- Lyophilized from sterile PBS, pH 7.4
-
储存条件
- 4 °C,-20 °C,-80 °C
-
储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
-
- Osteoactivin (GPNMB)
-
别名
- GPNMB
-
背景
-
Background: GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteoclasts, macrophages, dendritic cells, and tumor cells. It is suggested to influence osteoblast maturation, cell adhesion and migration. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages. Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury. The early-phase upregulation of Osteoactivin expression in the tubular epithelium in response to renal injury might play a role in triggering renal interstitial fibrosis via activation of matrix metalloproteinase expression and collagen remodeling in rats. Osteoactivin as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone.
Synonym: Transmembrane Glycoprotein NMB, Transmembrane Glycoprotein HGFIN, GPNMB, HGFIN,NMB,Osteoactivin
-
分子量
- 77.8 kDa
抗原
-
