Olfactomedin 4 Protein (OLFM4) (His tag)
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北京 101111
Quick Overview for Olfactomedin 4 Protein (OLFM4) (His tag) (ABIN7197233)
抗原
See all Olfactomedin 4 (OLFM4) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Olfactomedin 4 protein is labelled with His tag.
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原理
- Recombinant Human OLFM4 Protein (His Tag)
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序列
- Met 1-Gln 510
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产品特性
- A DNA sequence encoding the human OLFM4 (NP_006409.3) (Met 1-Gln 510) was fused with a polyhistidine tag at the C-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Olfactomedin 4 (OLFM4) (AA 1-510) protein (GST tag)
OLFM4 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
Olfactomedin 4 (OLFM4) proteinOLFM4 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, ELISA, IP
Olfactomedin 4 (OLFM4) proteinOLFM4 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, ELISA, IP
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- Olfactomedin 4 (OLFM4)
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别名
- OLFM4
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背景
- Antiapoptotic protein GW112,G-CSF-stimulated clone 1 protein,GW112,OLFM4,OLM4,Olfactomedin-4,hGC-1,hOLfD,Olfactomedin-4, also known as G-CSF-stimulated clone 1 protein, Antiapoptotic protein GW112, and OLFM4, is a secreted protein which contains one olfactomedin-like domain. The OLFM4 gene was recently reported to inhibit various apoptotic pathways and promote proliferation of cancer cells, suggesting that OLFM4 might serve as a diagnostic marker for human cancers. Thus, OLFM4 mRNA might be a useful tool to support the diagnosis of cancer, irrespective of the clinical stages. It is overexpressed in a number of human tumor types, especially in those of the digestive system. GW112 is associated with GRIM-19, a protein known to be involved in regulating cellular apoptosis. Functionally, GW112 could significantly attenuate the ability of GRIM19 to mediate retinoic acid-IFN-beta-mediated cellular apoptosis and apoptosis-related gene expression. In addition, GW112 demonstrated strong antiapoptotic effects in tumor cells treated with other stress exposures such as hydrogen peroxide. Finally, forced overexpression of GW112 in murine prostate tumor cells led to more rapid tumor formation in a syngeneic host. OLFM4 is an important regulator of cell death that plays important roles in tumor cell survival and tumor growth. GW112 has an antiapoptotic property against the cytotoxic agents-induced apoptosis. It suggested that GW112 could be an important mediator in NF kappaB-dependent tumorigenesis of digestive tract tissues.
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分子量
- 56.6 kDa
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基因ID
- 10562
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NCBI登录号
- NP_006409
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UniProt
- Q6UX06
抗原
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