NOL3 蛋白
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北京 101111
Quick Overview for NOL3 蛋白 (ABIN7318841)
抗原
See all NOL3 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human NOL3 Protein
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序列
- Met 1-Ser208
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产品特性
- Recombinant Human Nucleolar Protein 3 is produced by our E.coli expression system and the target gene encoding Met1-Ser208 is expressed.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (AA 1-208) protein (His-IF2DI Tag)
NOL3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (AA 1-208) protein (GST tag)NOL3 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (AA 1-208) protein (His-SUMO Tag)NOL3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. SDS
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (Transcript Variant 3) protein (His tag)NOL3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) protein (Myc-DYKDDDDK Tag)NOL3 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM PB, 150mm NaCl, 1 mM DTT, 1 mM EDTA, 10 % Glycerol, pH 7.0.
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储存液
- Dithiothreitol (DTT)
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注意事项
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- NOL3 (Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3))
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别名
- NOL3
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背景
- Apoptosis Repressor With CARD,Muscle-Enriched Cytoplasmic Protein,Myp,Nop30,Nucleolar Protein 3,Nucleolar Protein of 30 kDa,Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. It inhibits extrinsic apoptotic pathways through two different ways. Firstly, it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation. It has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53.
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分子量
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Calculated MW: 22.6 kDa
Observed MW: 29 kDa
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基因ID
- 8996
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UniProt
- O60936
抗原
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