NOL3 蛋白
Quick Overview for NOL3 蛋白 (ABIN7318841)
抗原
See all NOL3 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human NOL3 Protein
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序列
- Met 1-Ser208
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产品特性
- Recombinant Human Nucleolar Protein 3 is produced by our E.coli expression system and the target gene encoding Met1-Ser208 is expressed.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (AA 1-208) protein (His tag)
NOL3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (AA 1-208) protein (GST tag)NOL3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (Transcript Variant 3) protein (His tag)NOL3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (AA 1-208) protein (His-SUMO Tag)NOL3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) protein (Myc-DYKDDDDK Tag)NOL3 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Frozen, Liquid
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缓冲液
- Supplied as a 0.2 μm filtered solution of 25 mM TrisHCl, 1 mM DTT, 1 mM EDTA, 2 mM β-ME, 20 % Glycerol, pH 7.5.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- NOL3 (Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3))
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别名
- NOL3
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背景
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Background: Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. It inhibits extrinsic apoptotic pathways through two different ways. Firstly, it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation. It has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53.
Synonym: Nucleolar Protein 3, Apoptosis Repressor With CARD, Muscle-Enriched Cytoplasmic Protein, Myp, Nucleolar Protein of 30 kDa, Nop30
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分子量
- 22.6 kDa
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UniProt
- O60936
抗原
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