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NINJ1 Protein (Fc Tag)

This Recombinant NINJ1 protein is expressed in HEK-293 Cells.
产品编号 ABIN7321087
发货至: 中国

Quick Overview for NINJ1 Protein (Fc Tag) (ABIN7321087)

抗原

See all NINJ1 蛋白
NINJ1 (Ninjurin 1 (NINJ1))

蛋白类型

Recombinant

宿主

  • 7
  • 3
大鼠

资源

  • 3
  • 3
  • 2
  • 2
HEK-293 Cells

纯度

> 95 % as determined by SDS-PAGE
  • 标记

    This NINJ1 protein is labelled with Fc Tag.

    原理

    Recombinant Rat Ninjurin-1/NINJ1 Protein (Fc Tag)

    序列

    Met 1-Pro 79

    产品特性

    A DNA sequence encoding the rat NINJ1 (P70617) extracellular domain (Met 1-Pro 79) was fused with the Fc region of human IgG1 at the N-terminus.

    内毒素水平

    < 1.0 EU per μg of the protein as determined by the LAL method
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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Please refer to the printed manual for detailed information.

    缓冲液

    Lyophilized from sterile PBS, pH 7.4

    储存条件

    4 °C,-20 °C,-80 °C

    储存方法

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原

    NINJ1 (Ninjurin 1 (NINJ1))

    别名

    Ninjurin-1/NINJ1

    背景

    Background: Ninjurin-1, also known as NINJ1, is a member of the Ninjurin family of transmembrane (TM) proteins. It is expressed in CD19(+) CD10(+) B-cell progenitor cells and higher levels in B-lineage acute lymphoblastic leukemia cells. Ninjurin-1 is expressed also in a number of other adult and embryonic tissues, predominantly in epithelial cells. Its expression is upregulated after axotomy in neurons and in Schwann cells surrounding the distal nerve segment. Upregulated expression of ninjurin-1 has been identified as a marker of minimal residual disease in B-lineage acute lymphoblastic leukemia. It mediates homophilic adhesion, and promotes neurite extension of dorsal root ganglion neurons in vitro. Ninjurin-1 has been found to show a high expression level in the liver tissue of patients with hepatocellular carcinoma, and this seems to be associated with cases of cirrhosis and chronic viral hepatitis. It has been reported that NINJURIN increases p21 expression and induces cellular senescence in human hepatoma cells.

    Synonym: NINJ1

    分子量

    37 kDa

    UniProt

    P70617
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