MUC1 蛋白
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北京 101111
Quick Overview for MUC1 蛋白 (ABIN7317411)
抗原
See all MUC1 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human Mucin-1/MUC-1 Protein
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序列
- Met 1-Gly 167
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产品特性
- A DNA sequence encoding the human MUC1 isoform 2 (NP_001018016.1) extracellular domain (Met 1-Gly 167) was expressed with six amino acids (LEVLFQ) at the C-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Mucin 1 (MUC1) (AA 315-420) protein (GST tag)
MUC1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Mucin 1 (MUC1) (AA 24-158) (Active) protein (hFc Tag)MUC1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Mucin 1 (MUC1) (AA 24-380) (Active) protein (Fc Tag)MUC1 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Mucin 1 (MUC1) (AA 1036-1156) protein (Fc Tag)MUC1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. IA, ScA, ADA, AM
Mucin 1 (MUC1) (AA 1036-1156) protein (His tag)MUC1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. IA, ScA, ADA, AM
Mucin 1 (MUC1) (AA 1036-1155) protein (His tag)MUC1 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Mucin 1 (MUC1) (AA 890-1158) protein (His tag)MUC1 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- MUC1 (Mucin 1 (MUC1))
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别名
- Mucin-1/MUC-1
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背景
- Breast carcinoma-associated antigen DF3,CA 15-3,Cancer antigen 15-3,Carcinoma-associated mucin,Episialin,H23AG,KL-6,Krebs von den Lungen-6,MUC-1,Mucin-1,PEM,PEMT,PUM,Peanut-reactive urinary mucin,Polymorphic epithelial mucin,Tumor-associated epithelial me,Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. MUC-1 Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. The alpha subunit has cell adhesive properties. MUC-1 Can act both as an adhesion and an anti-adhesion protein. This protein May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. MUC-1 participated in modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, MUC-1 influences directly or indirectly the Ras/MAPK pathway. MUC-1 Promotes tumor progression and regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
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分子量
- 15.4 kDa
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基因ID
- 4582
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NCBI登录号
- NP_001018016
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UniProt
- P15941
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途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
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