MAP4K2 Protein (His-GST)
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Quick Overview for MAP4K2 Protein (His-GST) (ABIN7317061)
抗原
See all MAP4K2 蛋白蛋白类型
宿主
资源
纯度
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标记
- This MAP4K2 protein is labelled with His-GST.
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原理
- Recombinant Human MAP4K2/GC Kinase Protein (His & GST Tag)
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序列
- Met 1-Tyr 812
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产品特性
- A DNA sequence encoding the human MAP4K2 (AAH47865.1) (Met 1-Tyr 812) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 1-820) protein (GST tag)
MAP4K2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) protein (Myc-DYKDDDDK Tag)MAP4K2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as sterile solution of 50 mM Tris, 100 mM NaCl, pH 8.0
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))
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别名
- MAP4K2/GC Kinase
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背景
- BL44,GCK,MAP4K2,RAB8IP,Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein and MAP4K2, is a cytoplasm and peripheral membrane protein which belongs to theprotein kinase superfamily, STE Ser/Thr protein kinase family and STE20 subfamily. MAP4K2 contains oneCNH domain and oneprotein kinase domain. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. MAP4K2 can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. It is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1 / MEKK1. MAP4K2 enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. It may also play a role in the regulation of vesicle targeting or fusion.
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分子量
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Calculated MW: 119 kDa
Observed MW: 116 kDa
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基因ID
- 5871
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UniProt
- Q12851
抗原
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