MTSS1 Protein (His-MBP)
This Recombinant MTSS1 protein is expressed in 大肠杆菌（E. Coli）.
产品编号 ABIN7317313
发货至:
中国
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Quick Overview for MTSS1 Protein (His-MBP) (ABIN7317313)
抗原
See all MTSS1 蛋白
MTSS1
(Metastasis Suppressor 1 (MTSS1))
蛋白类型
Recombinant
宿主
人
资源
大肠杆菌（E. Coli）
纯度
> 80 % as determined by reducing SDS-PAGE.
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标记
- This MTSS1 protein is labelled with His-MBP.
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原理
- Recombinant Human MTSS1 Protein (aa1-250, His & MBP Tag)
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序列
- Met 1-Ser 250
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产品特性
- A DNA sequence encoding the human MTSS1 (EAW92073.1) N-terminal fragment (Met 1-Ser 250) was fused with an N-terminal polyhistidine-tagged MBP tag at the N-terminus.
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过滤
- 0.2 μm filtered
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Biological Activity Comment
- Not validated for activity
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- MTSS1 (Metastasis Suppressor 1 (MTSS1))
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别名
- MTSS1
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背景
- MIM,MIMA,MIMB,MTSS1 (Metastasis suppressor 1), also known as Missing in metastasis (MIM), is a tissue-specific regulator of plasma membrane dynamics. MTSS1 is well described for its function as a metastasis suppressor gene and is expressed in a variety of tissues. MTSS1 might be involved in shaping neuronal membranes in vivo. MTSS1 deforms phosphoinositide-rich membranes through its I-BAR domain and interacts with actin monomers through its WH2 domain. MTSS1/MIM was first identified as a metastasis suppressor missing in metastatic bladder carcinoma cell lines. MTSS1 is a prognostic indicator of disease-free survival in breast cancer patients and demonstrates the ability to play a role in governing the metastatic nature of breast cancer cells. MTSS1 may serve as a useful biomarker for the prediction of outcome of gastric cancer. The down-regulation of MTSS1 that may be caused by DNA methylation was also observed in many other types of cancer.Recent work proposed that MIM also potentiates Sonic hedgehog (Shh)-induced gene expression. MTSS1 as a multiple functional molecular player and has an important role in development, carcinogenesis and metastasis.
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分子量
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Calculated MW: 71.8 kDa
Observed MW: 66 kDa
抗原
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