LGALS1/Galectin 1 蛋白
Quick Overview for LGALS1/Galectin 1 蛋白 (ABIN7321171)
抗原
See all LGALS1/Galectin 1 (LGALS1) 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Rat Galectin-1/LGALS1 Protein
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序列
- Ala2-Glu135
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产品特性
- A DNA sequence encoding the rat Galectin1 (P11762) (Ala2-Glu135) was expressed and purified.
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Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 2-135) protein (Fc Tag)
LGALS1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 2-135) protein (Fc Tag)LGALS1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 1-135) protein (GST tag)LGALS1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 1-135) proteinLGALS1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % pure SDS
Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) proteinLGALS1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) proteinLGALS1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.5
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- LGALS1/Galectin 1 (LGALS1) (Lectin, Galactoside-Binding, Soluble, 1 (LGALS1))
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别名
- Galectin-1/LGALS1
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背景
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Background: Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the carbohydrate-binding site. It is a homodimer with a subunit molecular mass of 14.5 kDa, which contains six cysteine residues per subunit. The cysteine residues should be in a free state in order to maintain a molecular structure that is capable of showing lectin activity. This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumour progression including cell adhesion, migration and tumour-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation and allergies as well as host-pathogen interactions.
Synonym: Galectin1,Lgals1
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分子量
- 14.9 kDa
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UniProt
- P11762
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途径
- Carbohydrate Homeostasis
抗原
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