KYNU Protein (His tag)
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北京 101111
Quick Overview for KYNU Protein (His tag) (ABIN7196722)
抗原
See all KYNU 蛋白蛋白类型
生物活性
宿主
资源
纯度
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标记
- This KYNU protein is labelled with His tag.
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原理
- Recombinant Human KYNU/Kynureninase Protein (His Tag)(Active)
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序列
- Met 1- Asn 465
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产品特性
- A DNA sequence encoding the human KYNU (Q16719) (Met 1- Asn 465) was expressed with a polyhistidine tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Measured by its ability to oxidize 3-hydroxykynurenine.The specific activity is > 200 pmoles/min/μg.
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 116,946.14 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 145,985.55 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Kynureninase (L-Kynurenine Hydrolase) (KYNU) (AA 1-465) protein (His tag)
custom-made KYNU 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Kynureninase (L-Kynurenine Hydrolase) (KYNU) (AA 1-464) protein (His tag)custom-made KYNU 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Kynureninase (L-Kynurenine Hydrolase) (KYNU) (AA 1-307) protein (GST tag)KYNU 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Kynureninase (L-Kynurenine Hydrolase) (KYNU) (Active) protein (His tag)KYNU 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 94 % as determined by SDS-PAGE Active
Kynureninase (L-Kynurenine Hydrolase) (KYNU) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)KYNU 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 25 % gly
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- KYNU (Kynureninase (L-Kynurenine Hydrolase) (KYNU))
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别名
- KYNU/Kynureninase
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背景
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Background: Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein which belongs to the protein disulfide isomerase family. P4HB is highly abundant. In some cell types, it seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. P4HB localizes near CD4-enriched regions on lymphoid cell surfaces. It is identified by mass spectrometry in melanosome fractions from stage I to stage IV. P4HB reduces and may activate fusogenic properties of HIV-1 gp120 surface protein, thereby enabling HIV-1 entry into the cell. P4HB catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, it seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. P4HB may therefore cause structural modifications of exofacial proteins. Inside the cell, it seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, P4HB functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). P4HB may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.
Synonym: KYNUU
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分子量
- 53.7 kDa
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UniProt
- Q16719
抗原
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