Quick Overview for CDH6 Protein (His tag) (ABIN7320085)
抗原
See all CDH6 蛋白蛋白类型
宿主
资源
纯度
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标记
- This CDH6 protein is labelled with His tag.
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原理
- Recombinant Mouse Cadherin-6/CDH6 Protein (His Tag)
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序列
- Met1-Ala615
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产品特性
- A DNA sequence encoding the mouse CDH6 (P97326) (Met1-Ala615) was expressed with a C-terminal polyhistidine tag.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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K-Cadherin (CDH6) (AA 1-663) protein (GST tag)
CDH6 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
K-Cadherin (CDH6) (AA 19-615) protein (His tag)CDH6 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- CDH6 (K-Cadherin (CDH6))
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别名
- Cadherin-6/CDH6
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背景
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Background: Cadherins are a family of calcium-dependent, cell-cell adhesion molecules that play an important morphoregulatory role in a wide variety of tissues. Alterations in cadherin function have been implicated in tumor progression in a number of adenocarcinomas. Cadherin-6 (CDH6), also known as K-cadherin (KCAD), is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 is highly expressed in brain, cerebellum, and kidney, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected lung, pancreas, and gastric mucosa. Additionally, it is specifically expressed in the proximal tubule of normal kidneys and in renal cell cancer. Thus , Cadherin-6 is a new prognostic factor for renal cancer.
Synonym: cad6,cadherin-6,K-cadherin
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分子量
- 68.7 kDa
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UniProt
- P97326
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途径
- Cell-Cell Junction Organization
抗原
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