ISG15 蛋白
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北京 101111
Quick Overview for ISG15 蛋白 (ABIN7317338)
抗原
See all ISG15 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human ISG15/G1P2 Protein (mature form)
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序列
- Met 1-Gly 157
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产品特性
- A DNA sequence encoding the mature form of human ISG15 (AAH09507.1) (Met 1-Gly 157) was expressed and purified.
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过滤
- 0.2 μm filtered
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Biological Activity Comment
- Not validated for activity
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ISG15 Ubiquitin-Like Modifier (ISG15) (AA 1-157) protein (Calmodulin (CaM))
ISG15 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 98 % SDS
ISG15 Ubiquitin-Like Modifier (ISG15) (AA 1-165) protein (GST tag)ISG15 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
ISG15 Ubiquitin-Like Modifier (ISG15) (AA 2-157), (full length) protein (His tag)ISG15 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 90 % ELISA
ISG15 Ubiquitin-Like Modifier (ISG15) (AA 2-157), (full length) protein (GST tag)ISG15 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 90 % ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 50 mM Tris, pH 8.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))
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别名
- ISG15/G1P2
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背景
- G1P2,IP17,ISG15,Interferon-Induced 15 kDa Protein,Interferon-Induced 17 kDa Protein,UCRP,Ubiquitin Cross-Reactive Protein,Ubiquitin-Like Protein ISG15,hUCRP,Interferon-induced 17 kDa protein (ISG15), a 15- kDa protein of unique primary amino acid sequence, functions intracellularly as an ubiquitin homologue and a cytokine that induces production of IFN-gamma and augments NK / lymphokine-activated killer cell proliferation and function. ISG15 is secreted from monocytes and lymphocytes. ISG15 is an ubiquitin-like molecule that is strongly upregulated by type I interferons as a primary response to diverse microbial and cellular stress stimuli. Alterations in the ISG15 signalling pathway have also been found in several human tumour entities. In addition to being stimulated by type I interferon, expression of ISG15 is greatly induced by viral or bacterial infection through the Janus kinase / signal transducer and activator of transcription (Jak / STAT) signalling pathway. After induction, ISG15 is secreted by monocytes, B- and T-lymphocytes and fibroblasts. We demonstrate the novel way in which the function of the ISG15 protein is inhibited by influenza B virus, which strongly induces the ISG15 protein: a specific region of the influenza B virus NS1 protein, which includes part of its effector domain, blocks the covalent linkage of ISG15 to its target proteins both in vitro and in infected cells.
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分子量
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Calculated MW: 17.2 kDa
Observed MW: 15 kDa
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基因ID
- 9636
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UniProt
- P05161
抗原
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