ISG15 蛋白
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- 抗原 See all ISG15 蛋白
- ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 原理
- Recombinant Human ISG15/G1P2 Protein (mature form)
- 序列
- Met 1-Gly 157
- 产品特性
- A DNA sequence encoding the mature form of human ISG15 (AAH09507.1) (Met 1-Gly 157) was expressed and purified.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product ISG15 蛋白
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ISG15 Ubiquitin-Like Modifier (ISG15) (AA 1-157) protein (CaM)
ISG15 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 98 % by SDS - PAGE SDS
ISG15 Ubiquitin-Like Modifier (ISG15) (AA 1-165) protein (GST tag)ISG15 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
ISG15 Ubiquitin-Like Modifier (ISG15) (AA 1-100) protein (GST tag)ISG15 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
ISG15 Ubiquitin-Like Modifier (ISG15) (AA 2-155) protein (His tag)Crystallography grade ISG15 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
ISG15 Ubiquitin-Like Modifier (ISG15) (AA 2-157), (full length) protein (GST tag)ISG15 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 90 % ELISA
ISG15 Ubiquitin-Like Modifier (ISG15) (AA 2-157), (full length) protein (His tag)ISG15 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 90 % ELISA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 50 mM Tris, pH 8.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))
- 别名
- ISG15/G1P2 (ISG15 产品)
- 别名
- G1P2 Protein, IFI15 Protein, IP17 Protein, UCRP Protein, hUCRP Protein, ISG15 Protein, g1p2 Protein, si:rp71-1c23.2 Protein, G1p2 Protein, IGI15 Protein, Irfp Protein, ISG17 Protein, ISG17/UCRP Protein, ISG15 ubiquitin-like modifier Protein, ISG15 Protein, isg15 Protein, Isg15 Protein
- 背景
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Background: Interferon-induced 17 kDa protein (ISG15), a 15- kDa protein of unique primary amino acid sequence, functions intracellularly as an ubiquitin homologue and a cytokine that induces production of IFN-gamma and augments NK / lymphokine-activated killer cell proliferation and function. ISG15 is secreted from monocytes and lymphocytes. ISG15 is an ubiquitin-like molecule that is strongly upregulated by type I interferons as a primary response to diverse microbial and cellular stress stimuli. Alterations in the ISG15 signalling pathway have also been found in several human tumour entities. In addition to being stimulated by type I interferon, expression of ISG15 is greatly induced by viral or bacterial infection through the Janus kinase / signal transducer and activator of transcription (Jak / STAT) signalling pathway. After induction, ISG15 is secreted by monocytes, B- and T-lymphocytes and fibroblasts. We demonstrate the novel way in which the function of the ISG15 protein is inhibited by influenza B virus, which strongly induces the ISG15 protein: a specific region of the influenza B virus NS1 protein, which includes part of its effector domain, blocks the covalent linkage of ISG15 to its target proteins both in vitro and in infected cells.
Synonym: Ubiquitin-Like Protein ISG15, Interferon-Induced 15 kDa Protein, Interferon-Induced 17 kDa Protein, IP17, Ubiquitin Cross-Reactive Protein, hUCRP, ISG15, G1P2, UCRP
- 分子量
- 17.2 kDa
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