IL23 Protein (AA 22-196, AA 23-335)
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北京 101111
Quick Overview for IL23 Protein (AA 22-196, AA 23-335) (ABIN7320867)
抗原
See all IL23 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- AA 22-196, AA 23-335
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原理
- Recombinant Mouse IL-23
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序列
- Val22-Ala196&Met23-Ser335
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产品特性
- Recombinant Mouse Interleukin-23 is produced by our Baculovirus expression system and the target geneencoding Val22-Ala196&Met23-Ser335 is expressed.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Measured by its ability to induce STAT reporter activity in 293F human embryonic kidney cells. The ED50 for this effect is 125.44 ng/ml.
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Interleukin 23 (IL23) (Heterodimer) (Active) protein (His tag)
IL23 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by reducing SDS-PAGE. ELISA, CC Active
Interleukin 23 (IL23) (AA 22-196), (AA 23-335) (Active) proteinIL23 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE. CC Active
Interleukin 23 (IL23) (AA 22-196), (AA 23-335) protein (His tag)IL23 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- IL23 (Interleukin 23 (IL23))
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别名
- IL-23
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背景
- CLMF p40,IL-12 subunit p40,IL-23p19,NKSF2,SGRF,Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.
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分子量
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Calculated MW: 19.7&35.8 kDa
Observed MW: 40&20 kDa
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基因ID
- 83430
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UniProt
- Q9EQ14, P43432
抗原
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