IL-2 Protein (AA 21-169)
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北京 101111
Quick Overview for IL-2 Protein (AA 21-169) (ABIN7320817)
抗原
See all IL-2 (IL2) 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- AA 21-169
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原理
- Recombinant Mouse Interleukin-2/IL-2 Protein
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序列
- Ala21-Gln169
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产品特性
- Recombinant Mouse Interleukin-2 is produced by our E.coli expression system and the target gene encoding Ala21-Gln169 is expressed.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 0.01 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells.The specific activity of Recombinant Mouse IL-2 is ≥1x107 IU/mg.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from a 0.2 μm filtered solution of 20 mM Sodium Citrate, 0.2 % Tween 80, pH 3.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- IL-2 (IL2) (Interleukin 2 (IL2))
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别名
- Interleukin-2/IL-2
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背景
- POIL,OTTHUMP,Aldesleukin,IL 2,Interleukin 2,Involved in regulation of T cell clonal expansion,Lymphokine,OTTHUMP00000164090,POIL2,T Cell Growth Factor,T-cell growth facter,Interleukin-2,IL2,TCGF,T-cell growth factor,Il-2,Interleukin 2 (IL 2), also termed T-cell growth factor, is a member of the cytokine family which includes IL-4, IL-7, IL-9, IL-15 and IL-21. Each member of this family has a four alpha helix bundle. IL-2 signals through the IL-2 receptor, a complex consisting of tree subunits, termed alpha, beta and gamma. The IL-2 R gamma is shared by cytokine receptors of all members of cytokine family. Mature mouse IL-2 shares 56 % and 73 % aa sequence identity with human and rat IL-2, respectively. IL-2 is produced by CD4+ T cell, CD8+ T cells, gamma δ T cells, B cells, dendritic cells and eosinophils, and plays a vital role in key function of the immune system, tolerance and immunity, primarily via its potent stimulatory activity for T cells.Thus, IL-2 may be a key cytokine in the natural suppression of autoimmunity.
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分子量
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Calculated MW: 17.4 kDa
Observed MW: 17 kDa
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基因ID
- 16183
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UniProt
- P04351
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途径
- JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
抗原
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