IL-17 蛋白
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北京 101111
Quick Overview for IL-17 蛋白 (ABIN7320461)
抗原
See all IL-17 (IL17) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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原理
- Recombinant Mouse Interleukin-17/IL-17 Protein (Active)
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序列
- Thr 22-Ala158
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产品特性
- A DNA sequence encoding the mature form of mouse IL17a (Q62386) (Thr 22-Ala158) was expressed and purified.
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Biological Activity Comment
- 1. Measured by its binding ability in a functional ELISA. 2. Immobilized recombinant mouse IL17a at 10 μg/mL (100 μl/well) can bind human IL17Ra-Fc2h with a linear range of 16-500 ng/mL.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- IL-17 (IL17) (Interleukin 17 (IL17))
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别名
- Interleukin-17/IL-17
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背景
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Background: IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Synonym: Ctla-8,Ctla8,IL-17,IL-17A,Il17
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分子量
- 15.5 kDa
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UniProt
- Q62386
抗原
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