HIST1H3A 蛋白
This Recombinant HIST1H3A protein is expressed in 大肠杆菌（E. Coli）.
产品编号 ABIN7317606
发货至:
中国
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Quick Overview for HIST1H3A 蛋白 (ABIN7317606)
抗原
HIST1H3A
(Histone Cluster 1, H3a (HIST1H3A))
蛋白类型
Recombinant
宿主
人
资源
大肠杆菌（E. Coli）
纯度
> 95 % as determined by reducing SDS-PAGE.
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原理
- Recombinant Human Histone H3.1/HIST1H3A/H3FA Protein
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序列
- Met 1-Ala 136
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产品特性
- A DNA sequence encoding the native human HIST1H3A (NP_003520.1) (Met1-Ala136) was expressed. Human and Mouse HIST1H3A sequences are identical.
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过滤
- 0.2 μm filtered
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Biological Activity Comment
- Not validated for activity
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 2 mM β-Mercaptoethanol
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- HIST1H3A (Histone Cluster 1, H3a (HIST1H3A))
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别名
- Histone H3.1/HIST1H3A/H3FA
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背景
- H3/A,H3FA,HIST1H3A,HIST1H3B,HIST1H3C,HIST1H3D,HIST1H3E,HIST1H3F,HIST1H3G,HIST1H3H,HIST1H3I,HIST1H3J,Histone H3.1, also known as HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, is a member of thehistone H3 family which is a core component of nucleosome. It is expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
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分子量
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Calculated MW: 15.5 kDa
Observed MW: 15.5 kDa
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基因ID
- 8350
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NCBI登录号
- NP_003520
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UniProt
- P68431
抗原
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