Hemopexin Protein (HPX) (His tag)
Quick Overview for Hemopexin Protein (HPX) (His tag) (ABIN7319592)
抗原
See all Hemopexin (HPX) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Hemopexin protein is labelled with His tag.
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原理
- Recombinant Human Hemopexin/HPX Protein (His Tag)
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序列
- Thr24-His462
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产品特性
- Recombinant Human Hemopexin is produced by our Mammalian expression system and the target gene encoding Thr24-His462 is expressed with a 6His tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Hemopexin (HPX) (AA 24-460) protein (His tag)
HPX 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Hemopexin (HPX) (AA 24-462) protein (His tag)HPX 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Hemopexin (HPX) (AA 24-462) protein (His tag)HPX 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Hemopexin (HPX) protein (His tag)HPX 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Hemopexin (HPX) (AA 24-460) protein (His-IF2DI Tag)HPX 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Hemopexin (HPX) (AA 1-254) protein (GST tag)HPX 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Hemopexin (HPX) (AA 24-462) protein (His tag)HPX 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % by SDS - PAGE SDS
Hemopexin (HPX) (Active) protein (His tag)HPX 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
Hemopexin (HPX) proteinHPX 宿主: 人 宿主: Human Native >95 %
Hemopexin (HPX) (AA 24-460), (full length) protein (His tag)HPX 宿主: 大鼠 宿主: 酵母菌 Recombinant > 90 % ELISA
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限制
- 仅限研究用
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状态
- Frozen, Liquid
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缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM MES,150 mM NaCl, pH 5.5.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Hemopexin (HPX)
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别名
- Hemopexin/HPX
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背景
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Background: Hemopexin (HPX) is plasma glycoprotein belongs to the family of the acute-phase proteins whose synthesis is induced after an inflammatory event. Hemopexin with two four-bladed beta -propeller folds has been found in other proteins including collagenases and provides sites for protein-protein interactions. The liver is the major synthesizing organ. Hemopexin participates in maintaining and recycling the iron pool by utilizing its high binding affinity toward heme composed of protoporphyrin IX and iron. It also functions in preventing oxidation caused by heme after hemolysis. Hydrophobic heme molecules can intercalate into lipid membranes and participate in the oxidation of lipid membrane components through the Fenton reaction resulting in lipid peroxidation. Hemopexin undergoes a conformational change upon the binding of heme. The conformational change allows hemopexin to interact with a specific receptor, forming a complex which is then internalized. Heme concentrations in plasma increase after hemolysis, which is associated with several pathological conditions such as reperfusion injury and ischemia.
Synonym: Hemopexin,Hpx,Hpxn
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分子量
- 50.1 kDa
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UniProt
- P02790
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途径
- Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
抗原
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