HMOX1 蛋白
Quick Overview for HMOX1 蛋白 (ABIN7318568)
抗原
See all HMOX1 蛋白蛋白类型
宿主
资源
纯度
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                                            原理
- Recombinant Human HO-1/HMOX1 Protein
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                                            序列
- Met 1-Thr 261
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                                            产品特性
- Recombinant Human Heme Oxygenase 1 is produced by our E.coli expression system and the target gene encoding Met1-Thr261 is expressed.
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                                            内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
 
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                                            限制
- 仅限研究用
 
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                                            状态
- Frozen, Liquid
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                                            缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 1 mM EDTA, pH 7.4.
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                                            储存条件
- -20 °C
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                                            储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
 
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    - HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))
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                                            别名
- HO-1/HMOX1
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                                            背景
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                        Background: Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Synonym: Heme Oxygenase 1, HO-1, HMOX1, HO, HO1 
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                                            分子量
- 29.9 kDa
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                                            UniProt
- P09601
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                                            途径
- Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome
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