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Quick Overview for K-RAS Protein (His tag) (ABIN7319807)
抗原
See all K-RAS (KRAS) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This K-RAS protein is labelled with His tag.
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原理
- Recombinant Human KRAS(G12C, N-6His)
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序列
- Thr2-Cys185(Gly12Cys)
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产品特性
- Recombinant Human GTPase Kras is produced by our E.coli expression system and the target gene encoding Thr2-Cys185(Gly12Cys) is expressed with a 6His tag at the N-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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GTPase Kras (KRAS) (AA 1-189) protein (GST tag)
KRAS 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
GTPase Kras (KRAS) (AA 16-125) protein (GST tag)KRAS 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
GTPase Kras (KRAS) (AA 1-188) protein (GST tag)KRAS 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
GTPase Kras (KRAS) (AA 2-185) protein (mFc Tag)KRAS 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
GTPase Kras (KRAS) (AA 2-185) protein (Fc Tag)KRAS 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
GTPase Kras (KRAS) (AA 2-185) protein (His tag)KRAS 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- K-RAS (KRAS) (GTPase Kras (KRAS))
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别名
- KRAS
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物质类
- Viral Protein
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背景
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Background: K-Ras belongs to the small GTPase superfamily, Ras family. As other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. K-Ras functions as a molecular on/off switch. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. Besides essential function in normal tissue signaling, the mutation of a K-Ras gene is an essential step in the development of many cancers. Several germline K-Ras mutations have been found to be associated with Noonan syndrome[4] and cardio-facio-cutaneous syndrome. Somatic K-Ras mutations are found at high rates in Leukemias, colon cancer, pancreatic cancer and lung cancer.
Synonym: Ki-Ras, c-K-ras, KRAS2, RASK2, CFC2
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分子量
- 23.6 kDa
抗原
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