Follistatin Protein (FST) (Fc Tag)
Quick Overview for Follistatin Protein (FST) (Fc Tag) (ABIN7317802)
抗原
See all Follistatin (FST) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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标记
- This Follistatin protein is labelled with Fc Tag.
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原理
- Recombinant Human Follistatin/FST Protein (Fc Tag)(Active)
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序列
- Met 1-Trp 344
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产品特性
- A DNA sequence encoding the human FST isoform FST344 (NP_037541.1) (Met 1-Trp 344) was fused with the Fc region of human IgG1 at the C-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Biological Activity Comment
- 1. Measured by its ability to bind human INHBA-his in a functional ELISA.2. Measured by its ability to bind mouse INHBA-his in a functional ELISA.3. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.5-3 μg/mL in the presence of 10 ng/ml Recombinant Human ctivin A.
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Follistatin (FST) (AA 30-344) protein (His tag)
FST 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Follistatin (FST) (AA 30-317) protein (His-IF2DI Tag)FST 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Follistatin (FST) (AA 1-344) protein (GST tag)FST 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Follistatin (FST) (Active) protein (Fc Tag)FST 宿主: 小鼠 宿主: CHO Cells Recombinant > 90 % as determined by SDS-PAGE Active
Follistatin (FST) (Active) protein (His tag)FST 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
Follistatin (FST) proteinFST 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant 90,00% SDS
Follistatin (FST) proteinFST 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
Follistatin (FST) proteinFST 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant 90,00% SDS
Follistatin (FST) proteinFST 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
Follistatin (FST) proteinFST 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant 90,00% SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Follistatin (FST)
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别名
- Follistatin/FST
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背景
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Background: Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. follistatin are expressed and subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal, bone marrow, and placenta but perhaps most notably in anterior pituitary-the classical target tissue for inhibin, the activin-follistatin system may play a key role in early embryogenesis. Follistatin binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone follistatin is a binding protein to activin. Since activin binds to follistatin, it is imperative to determine the nature of the activin/follistatin binding complex.
Synonym: FS
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分子量
- 61.7 kDa
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NCBI登录号
- NP_037541
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途径
- Negative Regulation of Hormone Secretion
抗原
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