FLRT1 Protein (His tag)
Our Local Distributor
北京 101111
Quick Overview for FLRT1 Protein (His tag) (ABIN7317569)
抗原
See all FLRT1 蛋白蛋白类型
生物活性
宿主
资源
纯度
-
-
标记
- This FLRT1 protein is labelled with His tag.
-
原理
- Recombinant Human FLRT1 Protein (His Tag)(Active)
-
序列
- Met 1-Pro 524
-
产品特性
- A DNA sequence encoding the human FLRT1 extracellular domain (Q9NZU1-1) (Met 1-Pro 524) was expressed, fused with a polyhistidine tag at the C-terminus.
-
内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
-
Biological Activity Comment
- Measured by the ability of the immobilized protein to support the adhesion of Neuro-2A mouse neuroblastoma cells.When cells are added to coated plates(5μg/mL, 100μL/well), approximately 50%-70% will adhere after 1 hour at 37°C.
-
-
Fibronectin Leucine Rich Transmembrane Protein 1 (FLRT1) (AA 1-674) protein (GST tag)
FLRT1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Fibronectin Leucine Rich Transmembrane Protein 1 (FLRT1) proteinFLRT1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant WB, SDS, ELISA, IP
Fibronectin Leucine Rich Transmembrane Protein 1 (FLRT1) protein (Myc-DYKDDDDK Tag)FLRT1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Please refer to the printed manual for detailed information.
-
缓冲液
- Lyophilized from sterile PBS, pH 7.4
-
储存条件
- 4 °C,-20 °C,-80 °C
-
储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
-
- FLRT1 (Fibronectin Leucine Rich Transmembrane Protein 1 (FLRT1))
-
别名
- FLRT1
-
背景
-
Background: The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT1 is expressed in kidney and brain, which is a target for tyrosine phosphorylation mediated by FGFR1 and implicate a non-receptor Src family kinase (SFK). All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. The phosphorylation state of FLRT1, which is itself FGFR1 dependent, may play a critical role in the potentiation of FGFR1 signalling and may also depend on a SFK-dependent phosphorylation mechanism acting via the FGFR. This is consistent with an 'in vivo' role for FLRT1 regulation of FGF signalling via SFKs. Furthermore, the phosphorylation-dependent futile cycle mechanism controlling FGFR1 signalling is concurrently crucial for regulation of FLRT1-mediated neurite outgrowth. FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. They may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. FLRT3 shares 55 % amino acid sequence identity with FLRT1.
Synonym: Leucine-Rich Repeat Transmembrane Protein FLRT1, Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 1, FLRT1
-
分子量
- 57 kDa
抗原
-
