ECE2 Protein (His tag)
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Quick Overview for ECE2 Protein (His tag) (ABIN7317964)
抗原
See all ECE2 蛋白蛋白类型
宿主
资源
纯度
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标记
- This ECE2 protein is labelled with His tag.
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原理
- Recombinant Human ECE-2 Protein (His Tag)
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序列
- Gly 199-Trp 883
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产品特性
- A DNA sequence encoding the ectodomain of human endothelin converting enzyme 2 isoform A (NP_055508.3) (Gly 199-Trp 883) was fused with a polyhistidine tag at the N-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Endothelin Converting Enzyme 2 (ECE2) (AA 1-255) protein (GST tag)
ECE2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- ECE2 (Endothelin Converting Enzyme 2 (ECE2))
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别名
- ECE-2
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背景
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Background: Endothelin-converting enzyme 2, also known as ECE-2, is a metalloprotease that possesses many properties consistent with it being a neuropeptide-processing enzyme. Endothelin-converting enzymes (ECEs) are the key enzymes in the endothelin (ET) biosynthesis that catalyze the conversion of big ET, the biologically inactive precursor of mature ET. Two enzymes, termed ECE-1 and ECE-2, have been molecularly identified. ECE-2 is found primarily in neural tissues, with high levels of expression in midbrain, cerebellum, hypothalamus, frontal cortex and spinal cord and moderate levels in hippocampus and striatum. ECE-2 is strongly down-regulated in inferior parietal lobe from Alzheimer disease patients (at protein level). ECE-2 converts big endothelin-1 to endothelin-1. It is involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. ECE-2 may limit beta-amyloid peptide accumulation in brain. It may also have methyltransferase activity. A comparison of residues around the cleavage site revealed that ECE-2 exhibits a unique cleavage site selectivity that is related to but distinct from that of ECE-1.
Synonym: ECE2,hCG_2022032,KIAA0604,MGC17664,MGC2408,MGC78487
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分子量
- 80.2 kDa
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NCBI登录号
- NP_055508
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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