ERN1 Protein (AA 465-977) (His-GST)
Our Local Distributor
北京 101111
Quick Overview for ERN1 Protein (AA 465-977) (His-GST) (ABIN7317060)
抗原
See all ERN1 蛋白蛋白类型
生物活性
宿主
资源
纯度
-
-
产品特性
- AA 465-977
-
标记
- This ERN1 protein is labelled with His-GST.
-
原理
- Recombinant Human ERN1/IRE1 Protein (aa 465-977, His & GST Tag)
-
序列
- Pro 465-Leu 977
-
产品特性
- A DNA sequence encoding the human ERN1 isoform 1 (O75460-1) cytoplasmic domain (Pro 465-Leu 977) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
-
过滤
- 0.2 μm filtered
-
内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
-
Biological Activity Comment
- The specific activity was determined to be 5 nmol/min/mg using MBP as substrate
-
-
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 401-500) protein (GST tag)
ERN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 1-70) protein (GST tag)ERN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) protein (Myc-DYKDDDDK Tag)ERN1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4
-
储存条件
- -20 °C
-
储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
-
有效期
- 6 months
-
-
- ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
-
别名
- ERN1/IRE1
-
背景
- IRE1,IRE1P,IRE1a,hIRE1p,The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
-
分子量
-
Calculated MW: 86.0 kDa
Observed MW: 90 kDa
-
基因ID
- 2081
-
UniProt
- O75460
-
途径
- ER-Nucleus Signaling, Unfolded Protein Response
抗原
-
