DYRK3 Protein (His-GST)
This Recombinant DYRK3 protein is expressed in Baculovirus infected Insect Cells.
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产品编号 ABIN7317092
发货至:
中国
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Quick Overview for DYRK3 Protein (His-GST) (ABIN7317092)
抗原
See all DYRK3 蛋白
DYRK3
(Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))
蛋白类型
Recombinant
生物活性
Active
宿主
人
资源
Baculovirus infected Insect Cells
纯度
> 85 % as determined by reducing SDS-PAGE.
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标记
- This DYRK3 protein is labelled with His-GST.
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原理
- Recombinant Human DYRK3/REDK Protein (His & GST Tag)
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序列
- Met 1-Ser 588
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产品特性
- A DNA sequence encoding the human DYRK3 isoform 1 (O43781-1) (Met 1-Ser 588) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be 22 nmol/min/mg using synthetic DYRKtide peptide (RRRFRPASPLRGPPK) as substrate.
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Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3) (AA 1-568) protein (GST tag)
DYRK3 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP, KAA
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 0.5 mM PMSF, 10 % glycerol, pH 8.0
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储存液
- PMSF
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- DYRK3 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))
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别名
- DYRK3/REDK
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背景
- DYRK5,RED,REDK,hYAK3-2,Dual specificity tyrosine-phosphorylation-regulated kinase 3, also known as Regulatory erythroid kinase, REDK and DYRK3, is a nucleus protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase family and MNB/DYRK subfamily. DYRKs are an emerging family of dual-specificity kinases that play key roles in cell proliferation, survival, and development. DYRK3 contains oneprotein kinase domain. Isoform 1 and isoform 2 of DYRK3 are highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow. Isoform 2 of DYRK3 is the predominant form in testis. Isoform 1 of DYRK3 is the predominant form in fetal liver and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node, and thymus. DYRK3 is a negative regulator of EPO-dependent erythropoiesis. It may place an upper limit on red cell production during stress erythropoiesis. DYRK3 inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. It may also act by regulating CREB/CRE signaling. DYRK3 proved to effectively inhibit NFAT (nuclear factor of activated T cells) transcriptional response pathways and to co-immunoprecipitate with NFATc3. DYRK3 attenuates (and possibly apportions) red cell production selectively during anemia.
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分子量
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Calculated MW: 93.5 kDa
Observed MW: 80 kDa
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基因ID
- 8444
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UniProt
- O43781
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途径
- Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha
抗原
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