DUSP14 Protein (His-MBP)
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Quick Overview for DUSP14 Protein (His-MBP) (ABIN7317376)
抗原
See all DUSP14 蛋白蛋白类型
宿主
资源
纯度
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标记
- This DUSP14 protein is labelled with His-MBP.
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原理
- Recombinant Human DUSP14/MKP-6 Protein (His & MBP Tag)
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序列
- Met 1 -His 191
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产品特性
- A DNA sequence encoding the human DUSP14 (O95147) (Met 1 -His 191) was fused with an N-terminal polyhistidine-tagged MBP tag at the N-terminus.
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过滤
- 0.2 μm filtered
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Biological Activity Comment
- Not validated for activity
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 116,946.14 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 145,985.55 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Dual Specificity Phosphatase 14 (DUSP14) (AA 1-198) protein (His tag)
custom-made DUSP14 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Dual Specificity Phosphatase 14 (DUSP14) (AA 1-198) protein (His tag)custom-made DUSP14 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Dual Specificity Phosphatase 14 (DUSP14) (AA 1-198) protein (GST tag)DUSP14 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP, PAA
Dual Specificity Phosphatase 14 (DUSP14) protein (Myc-DYKDDDDK Tag)DUSP14 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Dual Specificity Phosphatase 14 (DUSP14) (AA 1-198), (full length) protein (His-SUMO Tag)DUSP14 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, pH 7.5
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- DUSP14 (Dual Specificity Phosphatase 14 (DUSP14))
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别名
- DUSP14/MKP-6
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背景
- MKP-L,MKP6,Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosphotyrosine and phosphoserine / phosphothreonine residues in substrates. Unlike many other DUSPs, DUSP14 only contains a catalytic domain within the C-terminal region. In signal transduction, DUSP14 has been considered as negative regulator of the mitogen-activated protein kinase (MAPK) / extracellular signal-regulated kinase 1 / 2 (ERK 1 / 2) pathway. DUSP14 phosphatase activity has been confirmed to be inhibited by PTP inhibitor IV. PTP inhibitor binds to the catalytic site of DUSP14. PTP inhibitor IV effectively and specifically inhibited DUSP14-mediated dephosphorylation of JNK, a member of the mitogen-activated protein kinase (MAPK) family through dephosphorylation of both the Ser / Thr and Tyr residues of MAPKs.
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分子量
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Calculated MW: 65.0 kDa
Observed MW: 60 kDa
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基因ID
- 11072
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UniProt
- O95147
抗原
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