DPP4 蛋白
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- 抗原 See all DPP4 蛋白
- DPP4 (Dipeptidyl-Peptidase 4 (DPP4))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 原理
- Recombinant Human DPP4/CD26 Protein(Active)
- 序列
- Asn29-Pro766
- 产品特性
- The native mature form of human DPPIV (NP_001926.2) extracellular domain (Asn 29-Pro 766) was expressed and purified.
- 纯度
- > 70 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method
- Biological Activity Comment
- 1. Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Pro-7-amido-4-methylcoumarin (GP-AMC). The specific activity is > 2,500 pmoles/min/μg. 2. Using the Octet RED System, the affinity constant (Kd) of Recombinant Human DPP4/CD26 Protein(Active)(Cat: PKSH033811) bound to Recombinant MERS-CoV Spike Protein (S1+S2 ECD, aa 1-1297, His Tag) (Cat: PKSV030236) was 33 nM. 3. Using the Octet RED System, the affinity constant (Kd) of Recombinant Human DPP4/CD26 Protein(Active)(Cat: PKSH033811) bound to Recombinant HCoV-HKU1 (Isolate N1) S1 Protein (His Tag) (Cat: PKSV030109) was 12 nM.
- Top Product
- Discover our top product DPP4 蛋白
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Dipeptidyl-Peptidase 4 (DPP4) protein (Fc Tag)
DPP4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Dipeptidyl-Peptidase 4 (DPP4) protein (His tag)DPP4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Dipeptidyl-Peptidase 4 (DPP4) (AA 29-766) protein (His tag)DPP4 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Dipeptidyl-Peptidase 4 (DPP4) (AA 29-766) protein (Fc Tag)DPP4 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Dipeptidyl-Peptidase 4 (DPP4) (AA 39-766) protein (His tag)DPP4 宿主: 人 宿主: Hi-5 Cells Recombinant > 95 % by SDS - PAGE SDS
Dipeptidyl-Peptidase 4 (DPP4) (AA 352-451) protein (GST tag)DPP4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Dipeptidyl-Peptidase 4 (DPP4) (AA 1-766) protein (GST tag)DPP4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Dipeptidyl-Peptidase 4 (DPP4) (Active) protein (Fc Tag)DPP4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 100 mM NaCl, 50 mM Tris, pH 7.5 Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- DPP4 (Dipeptidyl-Peptidase 4 (DPP4))
- 别名
- DPP4/CD26 (DPP4 产品)
- 别名
- ADABP Protein, ADCP2 Protein, CD26 Protein, DPPIV Protein, TP103 Protein, MGC81966 Protein, MOP9.8 Protein, MOP9_8 Protein, DPP4 Protein, si:ch73-2d23.3 Protein, Cd26 Protein, Dpp-4 Protein, THAM Protein, dipeptidyl peptidase 4 Protein, dipeptidyl-peptidase 4 S homeolog Protein, prolyl oligopeptidase family protein Protein, dipeptidyl-peptidase 4 Protein, dipeptidylpeptidase 4 Protein, DPP4 Protein, dpp4.S Protein, AT5G24260 Protein, dpp4 Protein, Dpp4 Protein
- 背景
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Background: Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). The soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). This causes an increase in glucose-dependent stimulation, resulting in a lowering of blood glucose levels. Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin (HbA(1c)) levels, either as monotherapy or as a combination with other antidiabetic agents. Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development, and are a new pharmacological class of drugs for treating Type 2 diabetes.
Synonym: ADABP Protein, Human, ADCP2 Protein, Human, CD26 Protein, Human, DPPIV Protein, Human, TP103 Protein, Human
- 分子量
- 85.4kDa
- NCBI登录号
- NP_001926
- 途径
- Peptide Hormone Metabolism, Regulation of Leukocyte Mediated Immunity
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