DPP4 蛋白
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北京 101111
Quick Overview for DPP4 蛋白 (ABIN7195427)
抗原
See all DPP4 蛋白蛋白类型
生物活性
宿主
资源
纯度
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原理
- Recombinant Human DPP4/CD26 Protein(Active)
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序列
- Asn29-Pro766
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产品特性
- The native mature form of human DPPIV (NP_001926.2) extracellular domain (Asn 29-Pro 766) was expressed and purified.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method
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Biological Activity Comment
- 1. Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Pro-7-amido-4-methylcoumarin (GP-AMC). The specific activity is > 2,500 pmoles/min/μg. 2. Using the Octet RED System, the affinity constant (Kd) of Recombinant Human DPP4/CD26 Protein(Active)(Cat: PKSH033811) bound to Recombinant MERS-CoV Spike Protein (S1+S2 ECD, aa 1-1297, His Tag) (Cat: PKSV030236) was 33 nM. 3. Using the Octet RED System, the affinity constant (Kd) of Recombinant Human DPP4/CD26 Protein(Active)(Cat: PKSH033811) bound to Recombinant HCoV-HKU1 (Isolate N1) S1 Protein (His Tag) (Cat: PKSV030109) was 12 nM.
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 150,642.20 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 145,985.55 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Dipeptidyl-Peptidase 4 (DPP4) (AA 1-760) protein (His tag)
custom-made DPP4 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Dipeptidyl-Peptidase 4 (DPP4) (AA 1-766) protein (His tag)custom-made DPP4 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Dipeptidyl-Peptidase 4 (DPP4) (AA 29-766) protein (His tag)DPP4 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Dipeptidyl-Peptidase 4 (DPP4) (AA 29-766) protein (Fc Tag)DPP4 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Dipeptidyl-Peptidase 4 (DPP4) (Active) protein (Fc Tag)DPP4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
Dipeptidyl-Peptidase 4 (DPP4) (AA 34-766) protein (His tag)DPP4 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Dipeptidyl-Peptidase 4 (DPP4) (AA 29-766) protein (His tag)DPP4 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Dipeptidyl-Peptidase 4 (DPP4) (AA 1-766) protein (GST tag)DPP4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Dipeptidyl-Peptidase 4 (DPP4) (AA 39-766) (Active) protein (His tag)DPP4 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % SDS, EAA Active
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile 100 mM NaCl, 50 mM Tris, pH 7.5 Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- DPP4 (Dipeptidyl-Peptidase 4 (DPP4))
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别名
- DPP4/CD26
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背景
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Background: Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). The soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). This causes an increase in glucose-dependent stimulation, resulting in a lowering of blood glucose levels. Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin (HbA(1c)) levels, either as monotherapy or as a combination with other antidiabetic agents. Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development, and are a new pharmacological class of drugs for treating Type 2 diabetes.
Synonym: ADABP Protein, Human, ADCP2 Protein, Human, CD26 Protein, Human, DPPIV Protein, Human, TP103 Protein, Human
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分子量
- 85.4kDa
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NCBI登录号
- NP_001926
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途径
- Peptide Hormone Metabolism, Regulation of Leukocyte Mediated Immunity
抗原
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