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DPP4 蛋白

Name: DPP4 蛋白
Brand: antibodies-online
SKU: ABIN7195427
Availability: OutOfStock

This Recombinant DPP4 protein is expressed in HEK-293 Cells.

产品编号 ABIN7195427

发货至: 中国

Datasheet as PDF

Quick Overview for DPP4 蛋白 (ABIN7195427)

抗原

See all DPP4 蛋白

DPP4 (Dipeptidyl-Peptidase 4 (DPP4))

蛋白类型

Recombinant

生物活性

Active

宿主

人

资源

HEK-293 Cells

纯度

> 70 % as determined by SDS-PAGE

Discover our top product DPP4 蛋白

原理

Recombinant Human DPP4/CD26 Protein(Active)

序列

Asn29-Pro766

产品特性

The native mature form of human DPPIV (NP_001926.2) extracellular domain (Asn 29-Pro 766) was expressed and purified.

内毒素水平

< 1.0 EU per μg of the protein as determined by the LAL method

Biological Activity Comment

1. Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Pro-7-amido-4-methylcoumarin (GP-AMC). The specific activity is > 2,500 pmoles/min/μg. 2. Using the Octet RED System, the affinity constant (Kd) of Recombinant Human DPP4/CD26 Protein(Active)(Cat: PKSH033811) bound to Recombinant MERS-CoV Spike Protein (S1+S2 ECD, aa 1-1297, His Tag) (Cat: PKSV030236) was 33 nM. 3. Using the Octet RED System, the affinity constant (Kd) of Recombinant Human DPP4/CD26 Protein(Active)(Cat: PKSH033811) bound to Recombinant HCoV-HKU1 (Isolate N1) S1 Protein (His Tag) (Cat: PKSV030109) was 12 nM.
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Product

表达系统

Conjugate

Origin

价格从

DPP4 Protein (AA 1-766) (His tag)

表达系统 HEK-293 Cells

Conjugate His tag

Origin Human

价格从 136,947.45 ¥

DPP4 Protein (AA 1-766) (Strep Tag)

表达系统 Cell-free protein synthesis (CFPS)

Conjugate Strep Tag

Origin Human

价格从 172,528.32 ¥

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Dipeptidyl-Peptidase 4 (DPP4) (AA 29-766) protein (Fc Tag)
DPP4 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Dipeptidyl-Peptidase 4 (DPP4) (AA 1-760) protein (His tag)
custom-made DPP4 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Dipeptidyl-Peptidase 4 (DPP4) (AA 1-766) protein (His tag)
custom-made DPP4 宿主: 人宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Dipeptidyl-Peptidase 4 (DPP4) (AA 29-766) protein (His tag)
DPP4 宿主: Cynomolgus, 猕猴宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Dipeptidyl-Peptidase 4 (DPP4) (AA 29-766) protein (Fc Tag)
DPP4 宿主: 人宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.

Dipeptidyl-Peptidase 4 (DPP4) (AA 39-766) protein (His tag)
DPP4 宿主: 人宿主: Hi-5 Cells Recombinant > 95 % by SDS - PAGE SDS

Dipeptidyl-Peptidase 4 (DPP4) (AA 1-766) protein (GST tag)
DPP4 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

Dipeptidyl-Peptidase 4 (DPP4) (Active) protein (Fc Tag)
DPP4 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active

Dipeptidyl-Peptidase 4 (DPP4) (AA 34-766) protein (His tag)
DPP4 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Dipeptidyl-Peptidase 4 (DPP4) (AA 29-766) protein (His tag)
DPP4 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

限制

仅限研究用
状态

Lyophilized

溶解方式

Please refer to the printed manual for detailed information.

缓冲液

Lyophilized from sterile 100 mM NaCl, 50 mM Tris, pH 7.5 Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.

储存条件

4 °C,-20 °C,-80 °C

储存方法

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
抗原

DPP4 (Dipeptidyl-Peptidase 4 (DPP4))

别名

DPP4/CD26

背景

Background: Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). The soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). This causes an increase in glucose-dependent stimulation, resulting in a lowering of blood glucose levels. Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin (HbA(1c)) levels, either as monotherapy or as a combination with other antidiabetic agents. Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development, and are a new pharmacological class of drugs for treating Type 2 diabetes.
Synonym: ADABP Protein, Human, ADCP2 Protein, Human, CD26 Protein, Human, DPPIV Protein, Human, TP103 Protein, Human

分子量

85.4kDa

NCBI登录号

NP_001926

途径

Peptide Hormone Metabolism, Regulation of Leukocyte Mediated Immunity