Desmocollin 2 Protein (DSC2) (His tag)
Quick Overview for Desmocollin 2 Protein (DSC2) (His tag) (ABIN7317758)
抗原
See all Desmocollin 2 (DSC2) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Desmocollin 2 protein is labelled with His tag.
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原理
- Recombinant Human DSC2/Desmocollin-2 Protein (His Tag)
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序列
- Met 1-Arg 684
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产品特性
- A DNA sequence encoding the extracellular domain (Met 1-Arg 684) of human DSC2 (Q02487-1) was expressed, with a C-terminal polyhistidine tag.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Desmocollin 2 (DSC2) (AA 1-847) protein (GST tag)
DSC2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Desmocollin 2 (DSC2) protein (Myc-DYKDDDDK Tag)DSC2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Desmocollin 2 (DSC2)
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别名
- DSC2/Desmocollin-2
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背景
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Background: DSC2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Like other desmocollins, murine DSC2 has two products, Dsc2a and Dsc2b, produced by alternative splicing of a 46 bp exon which encodes 11 COOH-terminal aa followed by an in-frame stop codon. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in DSC2 are associated with arrhythmogenic right ventricular dysplasia-11. DSC2 is Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSC2 may contribute to epidermal cell positioning by mediating differential adhesiveness between cells that express different isoforms.
Synonym: ARVD11,CDHF2,DG2,DGII/III,DSC3
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分子量
- 75 kDa
抗原
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