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CST3 Protein (His tag)

CST3 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
产品编号 ABIN7195330
发货至: 中国
  • 抗原 See all CST3 蛋白
    CST3 (Cystatin C (CST3))
    蛋白类型
    Recombinant
    宿主
    • 16
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    大鼠
    资源
    • 16
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    HEK-293 Cells
    标记
    This CST3 protein is labelled with His tag.
    原理
    Recombinant Rat Cystatin C/CST3 Protein (His Tag)
    序列
    Met 1-Ala 140
    产品特性
    A DNA sequence encoding the rat CST3 (P14841-1) (Met 1-Ala 140) was fused with a polyhistidine tag at the C-terminus.
    纯度
    > 95 % as determined by SDS-PAGE
    内毒素水平
    < 1.0 EU per μg of the protein as determined by the LAL method
    Top Product
    Discover our top product CST3 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile 20 mM HEPES, 150 mM NaCl, pH 7.0
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    CST3 (Cystatin C (CST3))
    别名
    Cystatin C/CST3 (CST3 产品)
    别名
    armd11 Protein, fb51d07 Protein, wu:fb24g06 Protein, wu:fb51d07 Protein, wu:fc55f03 Protein, zgc:136227 Protein, ARMD11 Protein, CysC Protein, CYSC Protein, cystatin C Protein, cystatin C L homeolog Protein, cystatin C (amyloid angiopathy and cerebral hemorrhage) Protein, cystatin 3 Protein, CST3 Protein, cst3.L Protein, cst3 Protein, cystatin 3 Protein, Cst3 Protein
    背景

    Background: Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal function, particularly to detect small reductions in glomerular filtration rate. The mature, active form of human cystatin C is a single non-glycosylated polypeptide chain consisting of 120 amino acid residues, with a molecular mass of 13,343-13,359 Da, and containing four characteristic disulfide-paired cysteine residues. Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of Cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. In almost all the clinical studies, Cystatin C demonstrated a better diagnostic accuracy than serum creatinine in discriminating normal from impaired kidney function, but controversial results have been obtained by comparing this protein with other indices of kidney disease, especially serum creatinine-based equations, such as early atherosclerosis, Alzheimer's dementia, vascular aneurysms, hyperhomocysteinaemia and other neurodegenerative diseases. Cystatin C could be a useful clinical tool to identify HIV-infected persons. In addition, its expression is up-regulated in malignance of certain tumor progression.

    Synonym: Aa1249,Ab1-341,Ab2-196,Ac1-114,Ac1262,Ac2-069,Ba2-693

    分子量
    14.7 kDa
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