COCH Protein (His tag)
This Recombinant COCH protein is expressed in HEK-293 Cells.
产品编号 ABIN7317572
发货至:
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Quick Overview for COCH Protein (His tag) (ABIN7317572)
抗原
See all COCH 蛋白
COCH
(Cochlin (COCH))
蛋白类型
Recombinant
宿主
人
资源
HEK-293 Cells
纯度
> 92 % as determined by reducing SDS-PAGE.
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标记
- This COCH protein is labelled with His tag.
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原理
- Recombinant Human Cochlin/COCH Protein (His Tag)
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序列
- Glu 25-Gln 550
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产品特性
- A DNA sequence encoding the mature form of human COCH (NP_001128530.1) (Glu 25-Gln 550) was expressed, with a polyhistidine tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Cochlin (COCH) (AA 1-494) protein (GST tag)
COCH 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- COCH (Cochlin (COCH))
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别名
- Cochlin/COCH
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背景
- COCH-5B2,COCH5B2,DFNA9,Cochlin, also known as COCH-5B2 and COCH, is a secreted protein which contains one LCCL domain and two VWFA domains. It is an abundant inner ear protein expressed as multiple isoforms. Its function is also unknown, but it is suspected to be an extracellular matrix component. Cochlin and type II collagen are major constituents of the inner ear extracellular matrix, and Cochlin constitutes 70 % of non-collagenous protein in the inner ear, the cochlin isoforms can be classified into three subgroups, p63s, p44s and p40s. The expression of cochlin is highly specific to the inner ear. Eleven missense mutation and one in-frame deletion have been reported in the COCH gene, causing hereditary progressive sensorineural hearing loss and vestibular dysfunction, deafness autosomal dominant type 9 (DFNA9). The co-localization of cochlin and type II collagen in the fibrillar substance in the subepithelial area indicate that cochlin may play a role in the structural homeostasis of the vestibule acting in concert with the fibrillar type II collagen bundles. Defects in COCH may contribute to Meniere disease which is an autosomal dominant disorder characterized by hearing loss associated with episodic vertigo.
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分子量
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Calculated MW: 59.4 kDa
Observed MW: 66&48&18 kDa
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基因ID
- 1690
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NCBI登录号
- NP_001128530
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UniProt
- O43405
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途径
- Sensory Perception of Sound
抗原
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