CLDN18.2 protein (His tag)
Quick Overview for CLDN18.2 protein (His tag) (ABIN7319933)
抗原
蛋白类型
宿主
资源
纯度
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标记
- His tag
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原理
- Recombinant Human CLDN18.2(N-6His,C-Avi)
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产品特性
- Biotinylated Recombinant Human CLDN18.2 is produced by our E.coli expression system and the targetgene encoding extracellular is expressed with a 6His tag at the N-terminus.
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内毒素水平
- < 1.0 EU per g as determined by the LAL method.
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Biological Activity Comment
- Test in progress
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CLDN18.2 protein
宿主: 人 宿主: HEK-293 Cells Synthetic Nanodisc
CLDN18.2 protein-VLP宿主: 人 宿主: HEK-293 Cells VLP
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限制
- 仅限研究用
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状态
- Frozen, Liquid
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缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM Tris, 8M Urea,150 mM NaCl, 5 mM β-ME, pH 8.5.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- CLDN18.2
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背景
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Background: Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2.IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is underinvestigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.
Synonym: Claudin-18.2, CLDN18
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分子量
- 12.6 kDa
抗原
-
