CDC37 蛋白
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- 抗原 See all CDC37 蛋白
- CDC37 (Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- Baculovirus infected Insect Cells
- 原理
- Recombinant Mouse CDC37/CDC37A Protein
- 序列
- Met1-Ala379
- 产品特性
- A DNA sequence encoding the mouse CDC37 (Q61081) (Met1-Ala379) was expressed with two additional amino acids (Gly & Pro) at the N-terminus.
- 纯度
- > 85 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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- Discover our top product CDC37 蛋白
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Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) (AA 1-378) protein (His tag)
CDC37 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) (AA 1-378) protein (GST tag)CDC37 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) protein (GST tag,His tag)CDC37 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 85 % as determined by SDS-PAGE
Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) (AA 1-378) protein (Strep Tag)Crystallography grade CDC37 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) (AA 1-379) protein (Strep Tag)Crystallography grade CDC37 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) (AA 2-378) protein (His tag)Crystallography grade CDC37 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) (AA 2-379) protein (His tag)Crystallography grade CDC37 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) protein (Myc-DYKDDDDK Tag)CDC37 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CDC37 (Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37))
- 别名
- CDC37/CDC37A (CDC37 产品)
- 别名
- CG12019 Protein, CPDR-1 Protein, CPDR-2 Protein, DROCPDR Protein, Dmel\\CG12019 Protein, E(sev)3B Protein, cdc37 Protein, Afu4g10010 Protein, P50CDC37 Protein, p50 Protein, p50Cdc37 Protein, CG12019 gene product from transcript CG12019-RA Protein, cell division cycle 37 homolog Protein, Hsp90 co-chaperone Cdc37 Protein, Cdc37p Protein, cell division cycle 37 Protein, Cdc37 Protein, cdc37 Protein, AFUA_4G10010 Protein, CDC37 Protein
- 背景
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Background: CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is though to play an important role in the establishment of signaling pathways controlling cell proliferation through targeting intrinsically unstable oncoprotein kinases such as Cdk-4, Raf-1, and src to the molecular chaperone Hsp90. Decreased Hsp90 expression can reduce the levels of microtubule-associated protein tau, whose overexpression may induce many diseases. CDC37 is considered as a co-chaperone that is classified to Hsp90's accessory proteins. It has been reported that suppression of Cdc37 destabilized tau, leading to its clearance, whereas cdc37 overexpression preserved tau.Cdc37 was found to co-localize with tau in neuronal cells and to physically interact with tau from human brain. Moreover, Cdc37 levels significantly increased with age.
Synonym: p50,p50Cdc37
- 分子量
- 44.7 kDa
- UniProt
- Q61081
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