CADM1 Protein (AA 1-377) (His tag)
Quick Overview for CADM1 Protein (AA 1-377) (His tag) (ABIN7195011)
抗原
See all CADM1 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 1-377
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标记
- This CADM1 protein is labelled with His tag.
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原理
- Recombinant Mouse SynCam/CADM1 Protein (aa 1-377, His Tag)
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序列
- Met1-His377
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产品特性
- A DNA sequence encoding the mouse Cadm1 (NP_061240.3) (Met1-His377) was expressed with a polyhistidine tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Cell Adhesion Molecule 1 (CADM1) (AA 45-374) protein (His tag)
CADM1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Cell Adhesion Molecule 1 (CADM1) (AA 48-388) protein (His tag)CADM1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Cell Adhesion Molecule 1 (CADM1) (Active) protein (Fc Tag)CADM1 宿主: 小鼠 宿主: 人细胞 Recombinant > 90 % as determined by SDS-PAGE Active
Cell Adhesion Molecule 1 (CADM1) (AA 45-374) protein (His tag)CADM1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85% by SDS-PAGE SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- CADM1 (Cell Adhesion Molecule 1 (CADM1))
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别名
- SynCam/CADM1
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背景
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Background: Members of the immunoglobulin superfamily often play key roles in intercellular adhesion. IGSF4 is a novel immunoglobulin (Ig)-like intercellular adhesion molecule. Three Ig-like domains are included in the extracellular domain of IGSF4 and mediate homophilic or heterophilic interactions independently of Ca2+. The cytoplasmic domain of IGSF4 contains the binding motifs that connect to actin fibers. Since IGSF4 has been characterized by several independent research groups, this molecule is called by three names, TSLC1, SgIGSF and SynCAM. IGSF4 was first characterized as a tumor suppressor of non-small cell lung cancer and termed TSLC1. It is a single-pass type I membrane protein which belongs to the nectin family, which may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. In addition, CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. In neuroblastoma, loss of CADM1 expression has recently been found in disseminated tumours with adverse outcome, prompting us to investigate its role in neuroblastoma tumour progression. The downregulation of CADM1 tumour suppressor gene expression is a critical event in neuroblastoma pathogenesis resulting in tumour progression.
Synonym: Cell adhesion molecule 1,Immunoglobulin superfamily member 4,IgSF4,Nectin-like protein 2,NECL-2,Synaptic cell adhesion molecule,SynCAM,Tumor suppressor in lung cancer 1,TSLC-1
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分子量
- 38.5 kDa
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NCBI登录号
- NP_061240
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation
抗原
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