Quick Overview for CADM1 Protein (Fc Tag) (ABIN7320714)
抗原
See all CADM1 蛋白蛋白类型
生物活性
宿主
资源
纯度
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标记
- This CADM1 protein is labelled with Fc Tag.
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原理
- Recombinant Mouse SynCam/CADM1 Protein (Fc Tag)(Active)
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序列
- Gln48-His388
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产品特性
- Recombinant Mouse Cell adhesion molecule 1 is produced by our Mammalian expression system and the target gene encoding Gln48-His388 is expressed with a Fc tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Biological Activity Comment
- Immobilized Human CADM1-Fc at 2μg/ml(100 μl/well) can bind Human CRTAMV-His(Cat: PKSH032286). The ED50 of Human SCRTAMV-His(Cat: PKSH032286) is 4.905 ug/ml .
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Cell Adhesion Molecule 1 (CADM1) (AA 45-374) protein (His tag)
CADM1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Cell Adhesion Molecule 1 (CADM1) (AA 48-388) protein (His tag)CADM1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Cell Adhesion Molecule 1 (CADM1) (AA 1-377) protein (His tag)CADM1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Cell Adhesion Molecule 1 (CADM1) (AA 45-374) protein (His tag)CADM1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85% by SDS-PAGE SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- CADM1 (Cell Adhesion Molecule 1 (CADM1))
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别名
- SynCam/CADM1
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背景
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Background: Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. CADM1 may contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, it may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. The protein acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. It may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Synonym: Cell adhesion molecule 1,Immunoglobulin superfamily member 4,IgSF4,Nectin-like protein 2,NECL-2,Synaptic cell adhesion molecule,SynCAM,Tumor suppressor in lung cancer 1,TSLC-1
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分子量
- 65.3 kDa
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NCBI登录号
- NP_061240
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation
抗原
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