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CD96 Protein (CD96) (His tag)

CD96 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
产品编号 ABIN7320155
发货至: 中国
  • 抗原 See all CD96 蛋白
    CD96
    蛋白类型
    Recombinant
    生物活性
    Active
    宿主
    • 18
    • 4
    • 1
    • 1
    • 1
    小鼠
    资源
    • 12
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    标记
    This CD96 protein is labelled with His tag.
    原理
    Recombinant Mouse CD96 Protein (His Tag)(Active)
    序列
    Met 1-Met 536
    产品特性
    A DNA sequence encoding the mouse CD96 (Q3U0X8) extracellular domain (Met 1-Met 536) was expressed, fused with a C-terminal polyhistidine tag.
    纯度
    > 90 % as determined by SDS-PAGE
    内毒素水平
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Biological Activity Comment
    1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant Mouse CD96 at 10 μg/ml (100 μl/well) can bind mouse PVR with a linear range of 6.4-160 ng/ml.
    Top Product
    Discover our top product CD96 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile PBS, pH 7.4
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    CD96
    别名
    CD96 (CD96 产品)
    别名
    1700109I12Rik Protein, Tactile Protein, TACTILE Protein, CD96 antigen Protein, CD96 molecule Protein, Cd96 Protein, CD96 Protein
    背景

    Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. The CD155 ligand CD96 is a member of the Ig superfamily. It's a immunoglobulin-like protein tentatively allocated to the repertoire of human NK receptors. NK cells recognize poliovirus receptor (PVR), a nectins and nectin-like protein family member serve to mediate cell-cell adhesion, cell migration, with the presence of an additional receptor, CD96. CD96 promotes NK cell adhesion to target cells expressing PVR, stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. The effect the cells with mutated CD96 protein lost adhesion and growth activities indicates that CD96 mutations may cause a form of the C syndrome by interfering with cell adhesion and growth.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    Synonym: T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein; CD96

    分子量
    58 kDa
    UniProt
    Q3U0X8
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