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CD5 Protein (CD5) (AA 24-370) (His tag)

This Recombinant CD5 protein is expressed in 人细胞.
产品编号 ABIN7320723
发货至: 中国

Quick Overview for CD5 Protein (CD5) (AA 24-370) (His tag) (ABIN7320723)

抗原

See all CD5 蛋白
CD5

蛋白类型

Recombinant

宿主

  • 19
  • 4
  • 4
  • 2
  • 1
小鼠

资源

  • 19
  • 4
  • 2
  • 2
  • 2
  • 1
人细胞

纯度

> 95 % as determined by SDS-PAGE
  • 产品特性

    AA 24-370

    标记

    This CD5 protein is labelled with His tag.

    原理

    Recombinant Mouse CD5 Protein (aa 24-370, His Tag)

    序列

    Gln24-Asn370

    产品特性

    Recombinant Mouse T-Cell Surface Glycoprotein CD5 is produced by our Mammalian expression system and the target gene encoding Gln24-Asn370 is expressed with a 6His tag at the C-terminus.

    内毒素水平

    < 1.0 EU per μg as determined by the LAL method.
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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Please refer to the printed manual for detailed information.

    缓冲液

    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

    储存条件

    4 °C,-20 °C,-80 °C

    储存方法

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原

    CD5

    别名

    CD5

    背景

    Background: CD5 is a transmembrane glycoprotein of the conserved scavenger receptor cysteine-rich (SRCR) superfamily and expressed on thymocytes, peripheral T cells and a subset of B cells (B1-a). Moreover, CD5 also was found expressed in small lymphocytic lymphoma, hairy cell leukaemia and mantle cell lymphoma cells. The long cytoplasmic tail of CD5 has no intrinsic enzymatic activity, but contains four tyrosine phosphorylation sites, including an immunoreceptor tyrosine-based (ITAM)-like motif (pseudo-ITAM) and an immunoreceptor tyrosine-based inhibitory (ITIM)-like motif (pseudo-ITIM), as well as multiple potential serine and threonine phosphorylation sites. It physically associates with the T cell antigen receptor (TCR) and B cell antigen receptor (BCR), where it negatively modulates the activation and differentiation signals transduced by these receptors. CD5 also plays an important role in protection from activation-induced cell death and in the recognition of pathogen associated molecular patterns (PAMPS) present on fungal surfaces.

    Synonym: T-cell surface glycoprotein CD5, CD5, CD5 antigen, CD5 antigen (p56-62), CD5 Molecule, LEU1T-cell surface glycoprotein CD5, Lymphocyte antigen T1,Leu-1, T1, Ly-1

    分子量

    38.9 kDa

    NCBI登录号

    NP_031676
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