Quick Overview for CD180 Protein (Fc Tag) (ABIN7320259)
抗原
See all CD180 蛋白蛋白类型
宿主
资源
纯度
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标记
- This CD180 protein is labelled with Fc Tag.
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原理
- Recombinant Mouse CD180/RP105/LY64 Protein (Fc Tag)
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序列
- Met 1-Ser 626
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产品特性
- A DNA sequence encoding the mouse CD180 (NP_032559.2) extracellular domain (Met 1-Ser 626) was fused with the Fc region of human IgG1 at the C-terminus.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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CD180 Molecule (CD180) (AA 21-626) protein (His tag)
CD180 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD180 Molecule (CD180) (Active) protein (His tag)CD180 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE Active
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- CD180 (CD180 Molecule (CD180))
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别名
- CD180/RP105/LY64
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背景
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Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD180, also known as RP105, is a B-cell surface molecule belonging to the family of pathogen receptors, Toll-like receptors (TLR). CD180 has an extracellular leucine-rich repeats and a short cytoplasmic tail. CD180 / RP105 interact with an extracellular molecule named MD1 and then together form the cell surface receptor complex RP105 / MD1 which induces B-cell activation in humans and mice, leading to proliferation and up-regulation of a costimulatory molecule, B7.2 / CD86. CD180 / RP105 also has a role in LPS response because B cells lacking RP105 show hyporesponsiveness to LPS.
Synonym: F630107B15,Ly78,RP105
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分子量
- 95 kDa
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NCBI登录号
- NP_032559
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途径
- Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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