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Quick Overview for CTSA Protein (His tag) (ABIN7320306)
抗原
See all CTSA 蛋白蛋白类型
宿主
资源
纯度
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标记
- This CTSA protein is labelled with His tag.
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原理
- Recombinant Mouse Cathepsin A/CTSA Protein (His Tag)
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序列
- Met 1-Tyr 474
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产品特性
- A DNA sequence encoding the mouse CTSA (P16675-1) (Met 1-Tyr 474) was expressed, with a C-terminal polyhistidine tag.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Cathepsin A (CTSA) (AA 1-480) protein (GST tag)
CTSA 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cathepsin A (CTSA) (AA 24-474) protein (His tag)CTSA 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 90 % SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile 25 mM Tris, 0.3M NaCl, pH 8.0
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- CTSA (Cathepsin A (CTSA))
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别名
- Cathepsin A/CTSA
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背景
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Background: Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against the rapid proteolytic degradation. Cathepsin A is a multicatalytic enzyme with deamidase and esterase in addition to carboxypeptidase activities. It was recently identified in human platelets as deamidase. In vitro, it hydrolyzes a variety of bioactive peptide hormones including tachykinins, suggesting that extralysosomal cathepsin A plays a role in regulation of bioactive peptide functions. It is a member of the alpha/beta hydrolase fold family and has been suggested to share a common ancestral relationship with other alpha/beta hydrolase fold enzymes, such as cholinesterases. Cathepsin A defects are linked to multiple forms of Galactosialidosis with a combined secondary deficiency of beta-galactosidase and neuraminidase. Cathepsin A is a key molecule in the onset of galactosialidosis and also highlight the therapeutic acts in vivo as an endothelin-1-inactivating enzyme and strongly confirm a crucial role of this enzyme in effective elastic fiber formation.
Synonym: AU019505,PPCA,Ppgb
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分子量
- 52.8 kDa
抗原
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