CSNK2A1/CK II alpha Protein (AA 1-391) (His-GST)
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Quick Overview for CSNK2A1/CK II alpha Protein (AA 1-391) (His-GST) (ABIN7320004)
抗原
See all CSNK2A1/CK II alpha (CSNK2A1) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 1-391
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标记
- This CSNK2A1/CK II alpha protein is labelled with His-GST.
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原理
- Recombinant Mouse CSNK2A1/CK2A1 Protein (His & GST Tag)
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序列
- Met1-Gln391
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产品特性
- A DNA sequence encoding the mouse CSNK2A1 (Q60737) (Met1-Gln391) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be 34 nmol/min/mg using casein as substrate.
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Mouse价格从 116,946.14 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Mouse价格从 145,985.55 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Casein Kinase 2 alpha 1 (CSNK2A1) (AA 1-391) protein (His tag)
custom-made CSNK2A1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Casein Kinase 2 alpha 1 (CSNK2A1) (AA 1-391) protein (His tag)custom-made CSNK2A1 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Casein Kinase 2 alpha 1 (CSNK2A1) (AA 1-391) protein (GST tag)CSNK2A1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Casein Kinase 2 alpha 1 (CSNK2A1) (AA 1-391) protein (His tag)CSNK2A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Casein Kinase 2 alpha 1 (CSNK2A1) (AA 6-344) protein (His-IF2DI Tag)CSNK2A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Casein Kinase 2 alpha 1 (CSNK2A1) (AA 1-391) (Active) proteinCSNK2A1 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
Casein Kinase 2 alpha 1 (CSNK2A1) (Active) protein (GST tag)CSNK2A1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 93 % as determined by reducing SDS-PAGE. Active
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, pH 8.0, 10 % glycerol.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))
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别名
- CSNK2A1/CK2A1
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背景
- Csnk2a1-rs4,Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser / Thr protein kinase family and CK2 subfamily. Casein kinase II (CSNK2A1) is a serine / threonine protein kinase that phosphorylates acidic proteins such as casein. This kinase is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. Casein kinase II (CSNK2A1) is a constitutively active, ubiquitously expressed serine / threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CSNK2A1 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CSNK2A1, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CSNK2A1 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CSNK2A1 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via th phosphorylation of Akt.
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分子量
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Calculated MW: 72.9 kDa
Observed MW: 65 kDa
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UniProt
- Q60737
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途径
- SARS-CoV-2 Protein Interactome
抗原
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