Calreticulin 3 Protein (CALR3)
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北京 101111
Quick Overview for Calreticulin 3 Protein (CALR3) (ABIN7318227)
抗原
See all Calreticulin 3 (CALR3) 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human Calreticulin-3/CALR3 Protein
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序列
- Thr 20-Leu384
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产品特性
- Recombinant Human calreticulin-3 is produced by our E.coli expression system and the target gene encoding Thr20-Leu384 is expressed.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Calreticulin 3 (CALR3) (AA 20-384) protein
CALR3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Calreticulin 3 (CALR3) (AA 20-384) protein (His-IF2DI Tag)CALR3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Calreticulin 3 (CALR3) (AA 21-384) protein (GST tag)CALR3 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
Calreticulin 3 (CALR3) protein (Myc-DYKDDDDK Tag)CALR3 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 5 % Trehalose, 5 % Mannitol, 0.02 % Tween 80, 1 mM EDTA, pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- Calreticulin 3 (CALR3)
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别名
- Calreticulin-3/CALR3
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背景
- CALR3,CRT2,Calreticulin-3,calreticulin-2,calsperin,Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. During spermatogenesis process, Calreticulin-3 may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19), it is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain.
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分子量
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Calculated MW: 42.9 kDa
Observed MW: 40-50 kDa
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基因ID
- 125972
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UniProt
- Q96L12
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途径
- Activation of Innate immune Response
抗原
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