Calmodulin 1 Protein (CALM1)
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北京 101111
Quick Overview for Calmodulin 1 Protein (CALM1) (ABIN7318225)
抗原
See all Calmodulin 1 (CALM1) 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human Calmodulin/CALM1 Protein
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序列
- Met 1-Lys149
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产品特性
- Recombinant Human Calmodulin is produced by our E.coli expression system and the target gene encoding Met1-Lys149 is expressed.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Calmodulin 1 (CALM1) (AA 2-149) protein (His-IF2DI Tag)
CALM1 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Calmodulin 1 (CALM1) protein (Myc-DYKDDDDK Tag)CALM1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from a 0.2 μm filtered solution of 50 mM NH4HCO3, pH 8.0 .
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- Calmodulin 1 (CALM1)
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别名
- Calmodulin/CALM1
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背景
- CALM,CALM1,CALM2,CALM3,CALML2,CAM,CAM1,CAM2,CAM3,CAMB,CAMC,CAMIII ,CaM,Calmodulin,Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the binding of Ca2+ is required for the activation of Calmodulin. Once bound to Ca2+, Calmodulin acts as part of a calcium signal transduction pathway by modifying its interactions with various target proteins such as kinases or phosphatases. Calmodulin is a small, highly conserved protein that is 148 amino acids long. The protein has two approximately symmetrical globular domains each containing a pair of EF-hand motifs (the N- and C-domain) separated by a flexible linker region for a total of four Ca2+ binding sites. Calmodulin mediates many crucial processes such as inflammation, metabolism, apoptosis, smooth muscle contraction, intracellular movement, short-term and long-term memory, and the immune response. Calmodulin is expressed in many cell types and can have different subcellular locations, including the cytoplasm, within organelles, or associated with the plasma or organelle membranes, but it is always found intracellularly.
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分子量
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Calculated MW: 16.8 kDa
Observed MW: 16 kDa
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UniProt
- P62158
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途径
- cAMP Metabolic Process, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Phototransduction, BCR Signaling
抗原
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